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Mouse Anti-HCCS Recombinant Antibody (CBFYH-0766) (CBMAB-H1670-FY)

This product is mouse antibody that recognizes HCCS. The antibody CBFYH-0766 can be used for immunoassay techniques such as: IP, WB.
See all HCCS antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYH-0766
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Immunogen
Cytochrome c purified from human heart
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA, 50% glycerol
Preservative
1.5 mM Sodium azide
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
holocytochrome c synthase (cytochrome c heme-lyase)
Introduction
The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
Human3052
Mouse15159
Rat317444
UniProt ID
HumanP53701
MouseP53702
RatD3ZL85
Alternative Names
Holocytochrome C Synthase; Microphthalamia With Linear Skin Defects; Holocytochrome C-Type Synthase; Cytochrome C Heme-Lyase; EC 4.4.1.17; CCHL
Function
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Biological Process
Animal organ morphogenesis Source: ProtInc
Cytochrome c-heme linkage Source: UniProtKB
Cellular Location
Mitochondrion inner membrane; Membrane
Involvement in disease
Linear skin defects with multiple congenital anomalies 1 (LSDMCA1):
A disorder characterized by dermal, ocular, neurological and cardiac abnormalities. LSDMCA1 main features are unilateral or bilateral microphthalmia, linear skin defects in affected females, and in utero lethality for males. Skin defects are limited to the face and neck, consisting of areas of aplastic skin that heal with age to form hyperpigmented areas. Additional features in female patients include agenesis of the corpus callosum, sclerocornea, chorioretinal abnormalities, infantile seizures, congenital heart defect, mental retardation, and diaphragmatic hernia. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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