Mouse Anti-HCCS Recombinant Antibody (CBFYH-0766) (CBMAB-H1670-FY)

Name: Mouse Anti-HCCS Recombinant Antibody (CBFYH-0766)
SKU: CBMAB-H1670-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-0766

Application

IP, WB

Immunogen

Cytochrome c purified from human heart

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% BSA, 50% glycerol

Preservative

1.5 mM Sodium azide

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

holocytochrome c synthase (cytochrome c heme-lyase)

Introduction

The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.

Entrez Gene ID

Human	3052
Mouse	15159
Rat	317444

UniProt ID

Human	P53701
Mouse	P53702
Rat	D3ZL85

Alternative Names

Holocytochrome C Synthase; Microphthalamia With Linear Skin Defects; Holocytochrome C-Type Synthase; Cytochrome C Heme-Lyase; EC 4.4.1.17; CCHL

Function

Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.

Biological Process

Animal organ morphogenesis Source: ProtInc
Cytochrome c-heme linkage Source: UniProtKB

Cellular Location

Mitochondrion inner membrane; Membrane

Involvement in disease

Linear skin defects with multiple congenital anomalies 1 (LSDMCA1):
A disorder characterized by dermal, ocular, neurological and cardiac abnormalities. LSDMCA1 main features are unilateral or bilateral microphthalmia, linear skin defects in affected females, and in utero lethality for males. Skin defects are limited to the face and neck, consisting of areas of aplastic skin that heal with age to form hyperpigmented areas. Additional features in female patients include agenesis of the corpus callosum, sclerocornea, chorioretinal abnormalities, infantile seizures, congenital heart defect, mental retardation, and diaphragmatic hernia. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.

Choi, H., Lee, K., Kim, D., Kim, S., & Lee, J. H. (2022). The implication of holocytochrome c synthase mutation in Korean familial hypoplastic amelogenesis imperfecta. Clinical Oral Investigations, 26(6), 4487-4498.

Sutherland, M. C., Mendez, D. L., Babbitt, S. E., Tillman, D. E., Melnikov, O., Tran, N. L., ... & Kranz, R. G. (2021). In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases. Elife, 10, e64891.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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