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Mouse Anti-HCN1 Recombinant Antibody (S70-28) (CBMAB-AP2673LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
S70-28
Application
AM, IHC, IP, WB
Immunogen
Fusion protein amino acids 778-910 (C terminus) of rat HCN1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1
Introduction
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Entrez Gene ID
Human348980
Mouse15165
Rat84390
UniProt ID
HumanO60741
MouseO88704
RatQ9JKB0
Alternative Names
Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1; Brain Cyclic Nucleotide-Gated Channel 1; BCNG-1; BCNG1; Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 1; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1; EIEE24; HAC-2;
Function
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084).

Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Biological Process
Apical protein localization Source: Ensembl
Cellular response to cAMP Source: UniProtKB
Negative regulation of synaptic transmission, glutamatergic Source: Ensembl
Potassium ion transmembrane transport Source: UniProtKB
Protein homotetramerization Source: UniProtKB
Regulation of ion transmembrane transport Source: UniProtKB-KW
Regulation of membrane depolarization Source: ComplexPortal
Regulation of membrane potential Source: UniProtKB
Retinal cone cell development Source: Ensembl
Sodium ion transmembrane transport Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Developmental and epileptic encephalopathy 24 (DEE24):
A disease characterized by early-onset seizures, intellectual disability of varying degrees, and behavioral disturbances or autistic features in most individuals.
Generalized epilepsy with febrile seizures plus 10 (GEFSP10):
An autosomal dominant neurologic disorder with incomplete penetrance, characterized by variable types of seizures including absence, tonic-clonic, febrile, focal, and eyelid myoclonia. Some patients have normal neurologic development. Others have mild-to-moderate intellectual disability or autism spectrum disorder.
Topology
Cytoplasmic: 1-142
Helical: 143-164
Extracellular: 165-173
Helical: 174-194
Cytoplasmic: 195-215
Helical: 216-236
Extracellular: 237-260
Helical: 261-281
Cytoplasmic: 282-295
Helical: 296-318
Extracellular: 319-344
Pore-forming: 345-366
Extracellular: 367-371
Helical: 372-392
Cytoplasmic: 393-890

Claveras Cabezudo, A., Feriel Khoualdi, A., & D’Avanzo, N. (2022). Computational Prediction of Phosphoinositide Binding to Hyperpolarization-Activated Cyclic-Nucleotide Gated Channels. Frontiers in Physiology, 13, 859087.

Mayar, S., Memarpoor-Yazdi, M., Makky, A., Eslami Sarokhalil, R., & D'Avanzo, N. (2022). Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids. Frontiers in Molecular Neuroscience, 15, 848540.

Santoro, B., & Shah, M. M. (2020). Hyperpolarization-activated cyclic nucleotide-gated channels as drug targets for neurological disorders. Annual review of pharmacology and toxicology, 60, 109-131.

Nishitani, A., Yoshihara, T., Tanaka, M., Kuwamura, M., Asano, M., Tsubota, Y., & Kuramoto, T. (2020). Muscle weakness and impaired motor coordination in hyperpolarization-activated cyclic nucleotide-gated potassium channel 1-deficient rats. Experimental animals, 69(1), 11-17.

Porro, A., Saponaro, A., Gasparri, F., Bauer, D., Gross, C., Pisoni, M., ... & Moroni, A. (2019). The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels. Elife, 8, e49672.

Zhong, L. Y., Fan, X. R., Shi, Z. J., Fan, Z. C., Luo, J., Lin, N., ... & Wei, Y. (2019). Hyperpolarization-activated cyclic nucleotide-gated ion (HCN) channels regulate PC12 cell Differentiation toward sympathetic neuron. Frontiers in Cellular Neuroscience, 13, 415.

He, J. T., Li, X. Y., Zhao, X., & Liu, X. (2019). Hyperpolarization-activated and cyclic nucleotide-gated channel proteins as emerging new targets in neuropathic pain. Reviews in the Neurosciences, 30(6), 639-649.

Chang, X., Wang, J., Jiang, H., Shi, L., & Xie, J. (2019). Hyperpolarization-activated cyclic nucleotide-gated channels: an emerging role in neurodegenerative diseases. Frontiers in molecular neuroscience, 12, 141.

Gross, C., Saponaro, A., Santoro, B., Moroni, A., Thiel, G., & Hamacher, K. (2018). Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel. Journal of Biological Chemistry, 293(33), 12908-12918.

Saponaro, A., Cantini, F., Porro, A., Bucchi, A., DiFrancesco, D., Maione, V., ... & Moroni, A. (2018). A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Elife, 7, e35753.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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