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Mouse Anti-HCN1 (AA 778-910) Recombinant Antibody (CBFYH-3341) (CBMAB-H0295-FY)

This product is mouse antibody that recognizes HCN1. The antibody CBFYH-3341 can be used for immunoassay techniques such as: ICC, IHC-P, IP, WB.
See all HCN1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYH-3341
Antibody Isotype
IgG1
Application
ICC, IHC-P, IP, WB

Basic Information

Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.09% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 778-910

Target

Full Name
Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1
Introduction
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
Entrez Gene ID
84390
UniProt ID
Q9JKB0
Alternative Names
Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1; Brain Cyclic Nucleotide-Gated Channel 1; BCNG-1; BCNG1; Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 1; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1; EIEE24; HAC-2
Function
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084).

Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Biological Process
Apical protein localization Source: Ensembl
Cellular response to cAMP Source: UniProtKB
Negative regulation of synaptic transmission, glutamatergic Source: Ensembl
Potassium ion transmembrane transport Source: UniProtKB
Protein homotetramerization Source: UniProtKB
Regulation of ion transmembrane transport Source: UniProtKB-KW
Regulation of membrane depolarization Source: ComplexPortal
Regulation of membrane potential Source: UniProtKB
Retinal cone cell development Source: Ensembl
Sodium ion transmembrane transport Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Developmental and epileptic encephalopathy 24 (DEE24):
A disease characterized by early-onset seizures, intellectual disability of varying degrees, and behavioral disturbances or autistic features in most individuals.
Generalized epilepsy with febrile seizures plus 10 (GEFSP10):
An autosomal dominant neurologic disorder with incomplete penetrance, characterized by variable types of seizures including absence, tonic-clonic, febrile, focal, and eyelid myoclonia. Some patients have normal neurologic development. Others have mild-to-moderate intellectual disability or autism spectrum disorder.
Topology
Cytoplasmic: 1-142
Helical: 143-164
Extracellular: 165-173
Helical: 174-194
Cytoplasmic: 195-215
Helical: 216-236
Extracellular: 237-260
Helical: 261-281
Cytoplasmic: 282-295
Helical: 296-318
Extracellular: 319-344
Pore-forming: 345-366
Extracellular: 367-371
Helical: 372-392
Cytoplasmic: 393-890

Claveras Cabezudo, A., Feriel Khoualdi, A., & D’Avanzo, N. (2022). Computational Prediction of Phosphoinositide Binding to Hyperpolarization-Activated Cyclic-Nucleotide Gated Channels. Frontiers in Physiology, 13, 859087.

Mayar, S., Memarpoor-Yazdi, M., Makky, A., Eslami Sarokhalil, R., & D'Avanzo, N. (2022). Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids. Frontiers in Molecular Neuroscience, 15, 848540.

Santoro, B., & Shah, M. M. (2020). Hyperpolarization-activated cyclic nucleotide-gated channels as drug targets for neurological disorders. Annual review of pharmacology and toxicology, 60, 109-131.

Nishitani, A., Yoshihara, T., Tanaka, M., Kuwamura, M., Asano, M., Tsubota, Y., & Kuramoto, T. (2020). Muscle weakness and impaired motor coordination in hyperpolarization-activated cyclic nucleotide-gated potassium channel 1-deficient rats. Experimental animals, 69(1), 11-17.

Porro, A., Saponaro, A., Gasparri, F., Bauer, D., Gross, C., Pisoni, M., ... & Moroni, A. (2019). The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels. Elife, 8, e49672.

Zhong, L. Y., Fan, X. R., Shi, Z. J., Fan, Z. C., Luo, J., Lin, N., ... & Wei, Y. (2019). Hyperpolarization-activated cyclic nucleotide-gated ion (HCN) channels regulate PC12 cell Differentiation toward sympathetic neuron. Frontiers in Cellular Neuroscience, 13, 415.

He, J. T., Li, X. Y., Zhao, X., & Liu, X. (2019). Hyperpolarization-activated and cyclic nucleotide-gated channel proteins as emerging new targets in neuropathic pain. Reviews in the Neurosciences, 30(6), 639-649.

Chang, X., Wang, J., Jiang, H., Shi, L., & Xie, J. (2019). Hyperpolarization-activated cyclic nucleotide-gated channels: an emerging role in neurodegenerative diseases. Frontiers in molecular neuroscience, 12, 141.

Gross, C., Saponaro, A., Santoro, B., Moroni, A., Thiel, G., & Hamacher, K. (2018). Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel. Journal of Biological Chemistry, 293(33), 12908-12918.

Saponaro, A., Cantini, F., Porro, A., Bucchi, A., DiFrancesco, D., Maione, V., ... & Moroni, A. (2018). A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Elife, 7, e35753.

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For research use only. Not intended for any clinical use.

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