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  • Rabbit Anti-HCN2 Recombinant Antibody (EG1490)

Rabbit Anti-HCN2 Recombinant Antibody (EG1490) (CBMAB-EN1781-LY)

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Basic Information

Host Animal
Rabbit
Clone
EG1490
Application
WB: 1:500~1:1000 ELISA: 1:40000
Immunogen
The antibody was produced against synthesized peptide derived from internal of human HCN2.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
Introduction
The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy.
Entrez Gene ID
Human610
Mouse15166
Rat114244
UniProt ID
HumanQ9UL51
MouseO88703
RatQ9JKA9
Alternative Names
BCNG2; HAC-1; BCNG-2
Function
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).
Biological Process
Cell-cell signaling Source: ProtInc
Cellular response to cAMP Source: UniProtKB
Cellular response to cGMP Source: UniProtKB
Membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Potassium ion transmembrane transport Source: UniProtKB
Regulation of ion transmembrane transport Source: UniProtKB-KW
Regulation of membrane depolarization Source: ComplexPortal
Regulation of membrane potential Source: UniProtKB
Sodium ion import across plasma membrane Source: BHF-UCL
Sodium ion transmembrane transport Source: UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-215
Helical: 216-236
Extracellular: 237-240
Helical: 241-261
Cytoplasmic: 262-288
Helical: 289-309
Extracellular: 310-317
Helical: 318-338
Cytoplasmic: 339-369
Helical: 370-390
Extracellular: 391-413
Pore-forming: 414-435
Extracellular: 436-440
Helical: 441-461
Cytoplasmic: 462-889
PTM
Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating.

Nordström, T., Andersson, L. C., & Åkerman, K. E. (2022). Role of hyperpolarization-activated cyclic nucleotide-gated channel HCN2 in embryonic neural stem cell proliferation and differentiation. Neurochemistry International, 159, 105387.

Forster, L. (2022). Regulation of the hyperpolarization-activated cyclic nucleotide gated ion channel 2, HCN2, by post-translational SUMOylation.

Forster, L. A., Jansen, L. A. R., Rubaharan, M., Murphy, A. Z., & Baro, D. J. (2020). Alterations in SUMOylation of the hyperpolarization‐activated cyclic nucleotide‐gated ion channel 2 during persistent inflammation. European Journal of Pain, 24(8), 1517-1536.

Yuan, L., Luo, L., Ma, X., Wang, W., Yu, K., Shi, H., ... & Xu, T. (2020). Chronic morphine induces cyclic adenosine monophosphate formation and hyperpolarization-activated cyclic nucleotide-gated channel expression in the spinal cord of mice. Neuropharmacology, 176, 108222.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-HCN2 (AA 761-863) Recombinant Antibody (CBFYH-0782) (CAT#: CBMAB-H0297-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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