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Mouse Anti-HCN3 (AA 660-779 ) Recombinant Antibody (CBFYH-0785) (CBMAB-H0275-FY)

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Basic Information

Host Animal
Mouse
Clone
CBFYH-0785
Application
WB, IHC, IF, AM
Immunogen
Fusion protein amino acids 660-779 of mouse HCN3
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 660-779
More Infomation

Target

Full Name
Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3
Introduction
This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human57657
Mouse15168
Rat114245
UniProt ID
HumanQ9P1Z3
MouseO88705
RatQ9JKA8
Alternative Names
Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3; KIAA1535
Function
Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.
Biological Process
Cellular response to cAMP Source: ComplexPortal
Cellular response to dopamine Source: Ensembl
Potassium ion transmembrane transport Source: UniProtKB
Regulation of ion transmembrane transport Source: UniProtKB-KW
Regulation of membrane depolarization Source: ComplexPortal
Regulation of membrane potential Source: UniProtKB
Response to cisplatin Source: Ensembl
Sodium ion transmembrane transport Source: UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-97
Helical: 98-118
Extracellular: 119-124
Helical: 125-145
Cytoplasmic: 146-171
Helical: 172-192
Extracellular: 193-201
Helical: 202-222
Cytoplasmic: 223-253
Helical: 254-274
Extracellular: 275-297
Pore-forming: 298-319
Extracellular: 320-329
Helical: 330-350
Cytoplasmic: 351-774

Li, D., Liu, X., Liu, H., Li, T., Jia, S., Wang, X., ... & Wang, Y. F. (2021). Key roles of cyclooxygenase 2-protein kinase A-hyperpolarization-activated cyclic nucleotide-gated channel 3 pathway in the regulation of oxytocin neuronal activity in lactating rats with intermittent pup-deprivation. Neuroscience, 452, 13-25.

Li, D., Liu, H., Liu, X., Wang, H., Li, T., Wang, X., ... & Wang, Y. F. (2020). Involvement of hyperpolarization-activated cyclic nucleotide-gated channel 3 in oxytocin neuronal activity in lactating rats with pup deprivation. ASN neuro, 12, 1759091420944658.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-HCN3 Recombinant Antibody (S141-28) (CAT#: CBMAB-AP2677LY)

Mouse Anti-HCN3 (AA 660-779 ) Recombinant Antibody (CBFYH-0784) (CAT#: CBMAB-H0274-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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