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Mouse Anti-HCRT Recombinant Antibody (CBXO-0439) (CBMAB-O0559-CQ)

This product is a mouse antibody that recognizes HCRT. The antibody CBXO-0439 can be used for immunoassay techniques such as: IHC-P, IHC-Fr.
See all HCRT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0439
Antibody Isotype
IgG1
Application
IHC-P, IHC-Fr

Basic Information

Immunogen
Human Orexin B
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hypocretin Neuropeptide Precursor
Introduction
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
Entrez Gene ID
UniProt ID
Alternative Names
Hypocretin Neuropeptide Precursor; Prepro-Orexin; Orexin; PPOX; OX; Hypocretin (Orexin) Neuropeptide Precursor
Function
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Biological Process
Chemical synaptic transmission Source: ProtInc
Eating behavior Source: GO_Central
Excitatory postsynaptic potential Source: Ensembl
Negative regulation of DNA replication Source: Ensembl
Negative regulation of potassium ion transport Source: Ensembl
Negative regulation of transmission of nerve impulse Source: Ensembl
Neuropeptide signaling pathway Source: UniProtKB-KW
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Positive regulation of calcium ion transport Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Positive regulation of transmission of nerve impulse Source: GO_Central
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Regulation of neurotransmitter secretion Source: GO_Central
Response to starvation Source: GO_Central
Sleep Source: GO_Central
Temperature homeostasis Source: GO_Central
Cellular Location
Rough endoplasmic reticulum; Cytoplasmic vesicle; Synapse. Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
Involvement in disease
Narcolepsy 1 (NRCLP1):
The disease is caused by variants affecting the gene represented in this entry. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
PTM
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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