Rabbit Anti-HCRTR1 Recombinant Antibody (EG1491) (CBMAB-EN1782-LY)

Name: Rabbit Anti-HCRTR1 Recombinant Antibody (EG1491)
SKU: CBMAB-EN1782-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1491

Application

IF: 1:100~1:500 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human HCRTR1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

hypocretin receptor 1

Introduction

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.

Entrez Gene ID

Human	3061
Mouse	230777
Rat	25593

UniProt ID

Human	O43613
Mouse	P58307
Rat	P56718

Alternative Names

OX1R

Function

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369).

Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).

Biological Process

Chemical synaptic transmission Source: ProtInc
Feeding behavior Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Regulation of cytosolic calcium ion concentration Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-46
Helical: 47-67
Cytoplasmic: 68-82
Helical: 83-105
Extracellular: 106-119
Helical: 120-140
Cytoplasmic: 141-160
Helical: 161-182
Extracellular: 183-213
Helical: 214-235
Cytoplasmic: 236-298
Helical: 299-321
Extracellular: 322-336
Helical: 337-360
Cytoplasmic: 361-425

Zhu, M., Zhang, H., Yang, H., Zhao, Z., Blair, H. T., Zhai, M., ... & Xie, M. (2022). Polymorphisms and association of GRM1, GNAQ and HCRTR1 genes with seasonal reproduction and litter size in three sheep breeds. Reproduction in Domestic Animals, 57(5), 532-540.

Pulver, A., Kiive, E., Kanarik, M., & Harro, J. (2020). Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender. Brain Research, 1746, 147013.

Gottschalk, M. G., Richter, J., Ziegler, C., Schiele, M. A., Mann, J., Geiger, M. J., ... & Domschke, K. (2019). Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes. Translational Psychiatry, 9(1), 75.

Harro, J., Laas, K., Eensoo, D., Kurrikoff, T., Sakala, K., Vaht, M., ... & Veidebaum, T. (2019). Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour. Neuropharmacology, 156, 107527.

Kowalska, M., Kapelusiak-Pielok, M., Grzelak, T., Wypasek, E., Kozubski, W., & Dorszewska, J. (2018). The new* G29A and G1222A of HCRTR1, 5-HTTLPR of SLC6A4 polymorphisms and hypocretin-1, serotonin concentrations in migraine patients. Frontiers in Molecular Neuroscience, 11, 191.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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