HCRTR1

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.

Full Name

hypocretin receptor 1

Function

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369).

Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).

Biological Process

Chemical synaptic transmission Source: ProtInc
Feeding behavior Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Regulation of cytosolic calcium ion concentration Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-46
Helical: 47-67
Cytoplasmic: 68-82
Helical: 83-105
Extracellular: 106-119
Helical: 120-140
Cytoplasmic: 141-160
Helical: 161-182
Extracellular: 183-213
Helical: 214-235
Cytoplasmic: 236-298
Helical: 299-321
Extracellular: 322-336
Helical: 337-360
Cytoplasmic: 361-425