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Rat Anti-HCRTR2 Recombinant Antibody (CBXO-0265) (CBMAB-O0044-CQ)

This product is a rat antibody that recognizes HCRTR2. The antibody CBXO-0265 can be used for immunoassay techniques such as: FC.
See all HCRTR2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXO-0265
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hypocretin (orexin) receptor 2
Introduction
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
Entrez Gene ID
387285
UniProt ID
P58308
Alternative Names
Hypocretin Receptor 2; Hypocretin (Orexin) Receptor 2; Hypocretin Receptor Type 2; Ox-2-R; Ox2-R; OX2R; Orexin Receptor Type 2; Orexin Type-2 Receptor; Orexin Receptor 2
Function
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369).

Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
Biological Process
Chemical synaptic transmission Source: ProtInc
Circadian sleep/wake cycle process Source: InterPro
Feeding behavior Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Regulation of circadian sleep/wake cycle, wakefulness Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-54
Helical: 55-75
Cytoplasmic: 76-88
Helical: 89-110
Extracellular: 111-127
Helical: 128-150
Cytoplasmic: 151-170
Helical: 171-191
Extracellular: 192-222
Helical: 223-243
Cytoplasmic: 244-304
Helical: 305-326
Extracellular: 327-342
Helical: 343-366
Cytoplasmic: 367-444

Papasavva, M., Katsarou, M. S., Vikelis, M., Mitropoulou, E., Dermitzakis, E. V., Papakonstantinou, S., ... & Drakoulis, N. (2020). Analysis of HCRTR2, GNB3, and ADH4 Gene polymorphisms in a Southeastern European Caucasian cluster headache population. Journal of Molecular Neuroscience, 70, 467-474.

Firouzabadi, N., Navabzadeh, N., Moghimi-Sarani, E., & Haghnegahdar, M. (2020). Orexin/hypocretin type 2 receptor (HCRTR2) gene as a candidate gene in sertraline-associated insomnia in depressed patients. Neuropsychiatric Disease and Treatment, 1121-1128.

Yang, J., Yu, S. Y., Yang, J., Kong, J., Liang, F. R., & Lv, Z. T. (2020). No association between G1246A polymorphism in HCRTR2 gene and risk of cluster headache: Evidence from an updated meta-analysis of observational studies. Frontiers in Genetics, 11, 560517.

Fourier, C., Ran, C., Steinberg, A., Sjöstrand, C., Waldenlind, E., & Belin, A. C. (2019). Analysis of HCRTR2 gene variants and cluster headache in Sweden. Headache: The Journal of Head and Face Pain, 59(3), 410-417.

Karami, N., Aligholi, H., Kalantari, T., & Zeraatpishe, M. (2018). P50: Selective HCRTR2 Antagonism Increases Embryonic Mouse Cortex Neural Stem Progenitor Cells Proliferation. The Neuroscience Journal of Shefaye Khatam, 6(2), 81-81.

Fan, Z., Hou, L., Wan, D., Ao, R., Zhao, D., & Yu, S. (2018). Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. The Journal of Headache and Pain, 19, 1-7.

Popescu, C. (2023). Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype. Journal of Neurology, 1-7.

Trauner, D., & Vepřek, N. A. (2020). A Vincamine-Derived HCRTR2 Agonist Prevents Morphine-Seeking Behavior in Mouse Models. Synfacts, 16(06), 0724.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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