HCRTR2

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq]

hypocretin (orexin) receptor 2

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369).

Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).

Chemical synaptic transmission Source: ProtInc
Circadian sleep/wake cycle process Source: InterPro
Feeding behavior Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Regulation of circadian sleep/wake cycle, wakefulness Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: UniProtKB

Cell membrane

Extracellular: 1-54
Helical: 55-75
Cytoplasmic: 76-88
Helical: 89-110
Extracellular: 111-127
Helical: 128-150
Cytoplasmic: 151-170
Helical: 171-191
Extracellular: 192-222
Helical: 223-243
Cytoplasmic: 244-304
Helical: 305-326
Extracellular: 327-342
Helical: 343-366
Cytoplasmic: 367-444