HCRTR2

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq]
Full Name
hypocretin (orexin) receptor 2
Function
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369).

Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
Biological Process
Chemical synaptic transmission Source: ProtInc
Circadian sleep/wake cycle process Source: InterPro
Feeding behavior Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Regulation of circadian sleep/wake cycle, wakefulness Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-54
Helical: 55-75
Cytoplasmic: 76-88
Helical: 89-110
Extracellular: 111-127
Helical: 128-150
Cytoplasmic: 151-170
Helical: 171-191
Extracellular: 192-222
Helical: 223-243
Cytoplasmic: 244-304
Helical: 305-326
Extracellular: 327-342
Helical: 343-366
Cytoplasmic: 367-444
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Anti-HCRTR2 antibodies

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Rat Anti-HCRTR2 Recombinant Antibody (CBXO-0265) (CBMAB-O0044-CQ)

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Target: HCRTR2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXO-0265
Application*: F
Datasheet SDS

Mouse Anti-HCRTR2 Recombinant Antibody (CBFYC-0059) (CBMAB-C0066-FY)

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Target: HCRTR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0059
Application*: F
Datasheet SDS

Mouse Anti-HCRTR2 (AA 1-54) Recombinant Antibody (CBFYH-0789) (CBMAB-H1695-FY)

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Target: HCRTR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0789
Application*: E, WB
Datasheet SDS

Mouse Anti-HCRTR2 Recombinant Antibody (OX108) (CBMAB-O0552-CQ)

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Target: HCRTR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: OX108
Application*: F
Datasheet SDS

Mouse Anti-HCRTR2 Recombinant Antibody (OX102) (CBMAB-O0177-CQ)

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Target: HCRTR2
Host: Mouse
Specificity: Rat
Clone: OX102
Application*: IF, F
Datasheet SDS

Rat Anti-HCRTR2 Recombinant Antibody (OX110) (CBMAB-O0176-CQ)

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Target: HCRTR2
Host: Rat
Specificity: Mouse
Clone: OX110
Application*: F
Datasheet SDS

Mouse Anti-HCRTR2 Recombinant Antibody (CBXO-0010) (CBMAB-O0175-CQ)

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Target: HCRTR2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXO-0010
Application*: E, WB
Datasheet SDS

Mouse Anti-HCRTR2 Recombinant Antibody (1E3) (CBMAB-O0174-CQ)

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Target: HCRTR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E3
Application*: E, IR, WB
Datasheet SDS

Mouse Anti-HCRTR2 (AA 1-444) Recombinant Antibody (CBXO-0386) (CBMAB-O0173-CQ)

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Target: HCRTR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXO-0386
Application*: IH
Datasheet SDS

Mouse Anti-HCRTR2 Recombinant Antibody (CBXO-0266) (CBMAB-O0100-CQ)

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Target: HCRTR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0266
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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