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Mouse Anti-HDAC11 Recombinant Antibody (1C2-2G5) (CBMAB-A3796-LY)

The product is antibody recognizes HDAC11. The antibody 1C2-2G5 immunoassay techniques such as: WB, ELISA.
See all HDAC11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C2-2G5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HDAC11 (AAH09676, 1 a.a. ~ 347 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Histone Deacetylase 11
Introduction
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants
Entrez Gene ID
79885
UniProt ID
Q96DB2
Alternative Names
FLJ22237
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Biological Process
Chromatin organization Source: UniProtKB
Histone deacetylation Source: UniProtKB
Oligodendrocyte development Source: Ensembl
Cellular Location
Nucleus

Chen, H., Xie, C., Chen, Q., & Zhuang, S. (2022). HDAC11, an emerging therapeutic target for metabolic disorders. Frontiers in Endocrinology, 13, 989305.

Yao, F., Jin, Z., Zheng, Z., Lv, X., Ren, L., Yang, J., ... & Lin, R. (2022). HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells. Cell death discovery, 8(1), 112.

Wen, Y., Zhang, X., Li, X., Tian, L., Shen, S., Ma, J., & Ai, F. (2022). Histone deacetylase (HDAC) 11 inhibits matrix metalloproteinase (MMP) 3 expression to suppress colorectal cancer metastasis. Journal of Cancer, 13(6), 1923.

Bi, L., Ren, Y., Feng, M., Meng, P., Wang, Q., Chen, W., ... & Wang, Y. (2021). HDAC11 regulates glycolysis through the LKB1/AMPK signaling pathway to maintain hepatocellular carcinoma stemness. Cancer Research, 81(8), 2015-2028.

Bora-Singhal, N., Mohankumar, D., Saha, B., Colin, C. M., Lee, J. Y., Martin, M. W., ... & Chellappan, S. (2020). Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2. Scientific reports, 10(1), 4722.

Liu, S. S., Wu, F., Jin, Y. M., Chang, W. Q., & Xu, T. M. (2020). HDAC11: a rising star in epigenetics. Biomedicine & pharmacotherapy, 131, 110607.

Wang, W., Ding, B., Lou, W., & Lin, S. (2020). Promoter hypomethylation and miR-145-5p downregulation-mediated HDAC11 overexpression promotes sorafenib resistance and metastasis of hepatocellular carcinoma cells. Frontiers in cell and developmental biology, 8, 724.

Heim, C. E., Bosch, M. E., Yamada, K. J., Aldrich, A. L., Chaudhari, S. S., Klinkebiel, D., ... & Kielian, T. (2020). Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection. Nature microbiology, 5(10), 1271-1284.

Cao, J., Sun, L., Aramsangtienchai, P., Spiegelman, N. A., Zhang, X., Huang, W., ... & Lin, H. (2019). HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proceedings of the National Academy of Sciences, 116(12), 5487-5492.

Yanginlar, C., & Logie, C. (2018). HDAC11 is a regulator of diverse immune functions. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1861(1), 54-59.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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