Canine Recombinant HDAC11, Active protein, GST Tag (V2LY-0526-LY1256)

Name: Canine Recombinant HDAC11, Active protein, GST Tag
SKU: V2LY-0526-LY1256
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Canine

Tag

GST Tag

Protein Construction

This product is Canine Recombinant HDAC11, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 66 kDa.

Molecule Mass

66 kDa

Sequence

Amino Acid: Full Length

Species

Canine

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Histone Deacetylase 11

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Biological Process

Chromatin organization Source: UniProtKB
Histone deacetylation Source: UniProtKB
Oligodendrocyte development Source: Ensembl

Cellular Location

Nucleus

Chen, H., Xie, C., Chen, Q., & Zhuang, S. (2022). HDAC11, an emerging therapeutic target for metabolic disorders. Frontiers in Endocrinology, 13, 989305.

Yao, F., Jin, Z., Zheng, Z., Lv, X., Ren, L., Yang, J., ... & Lin, R. (2022). HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells. Cell death discovery, 8(1), 112.

Wen, Y., Zhang, X., Li, X., Tian, L., Shen, S., Ma, J., & Ai, F. (2022). Histone deacetylase (HDAC) 11 inhibits matrix metalloproteinase (MMP) 3 expression to suppress colorectal cancer metastasis. Journal of Cancer, 13(6), 1923.

Bi, L., Ren, Y., Feng, M., Meng, P., Wang, Q., Chen, W., ... & Wang, Y. (2021). HDAC11 regulates glycolysis through the LKB1/AMPK signaling pathway to maintain hepatocellular carcinoma stemness. Cancer Research, 81(8), 2015-2028.

Bora-Singhal, N., Mohankumar, D., Saha, B., Colin, C. M., Lee, J. Y., Martin, M. W., ... & Chellappan, S. (2020). Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2. Scientific reports, 10(1), 4722.

Liu, S. S., Wu, F., Jin, Y. M., Chang, W. Q., & Xu, T. M. (2020). HDAC11: a rising star in epigenetics. Biomedicine & pharmacotherapy, 131, 110607.

Wang, W., Ding, B., Lou, W., & Lin, S. (2020). Promoter hypomethylation and miR-145-5p downregulation-mediated HDAC11 overexpression promotes sorafenib resistance and metastasis of hepatocellular carcinoma cells. Frontiers in cell and developmental biology, 8, 724.

Heim, C. E., Bosch, M. E., Yamada, K. J., Aldrich, A. L., Chaudhari, S. S., Klinkebiel, D., ... & Kielian, T. (2020). Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection. Nature microbiology, 5(10), 1271-1284.

Cao, J., Sun, L., Aramsangtienchai, P., Spiegelman, N. A., Zhang, X., Huang, W., ... & Lin, H. (2019). HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proceedings of the National Academy of Sciences, 116(12), 5487-5492.

Yanginlar, C., & Logie, C. (2018). HDAC11 is a regulator of diverse immune functions. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1861(1), 54-59.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant HDAC11, Active protein, GST Tag (CAT#: V2LY-0526-LY1528)

Human Recombinant HDAC11, Active protein, GST Tag (CAT#: V2LY-0526-LY4464)

Mouse Recombinant HDAC11, Active protein, GST Tag (CAT#: V2LY-0526-LY8386)

Rat Recombinant HDAC11, Active protein, GST Tag (CAT#: V2LY-0526-LY9411)

Human HDAC11 ELISA Kit (CAT#: V2LY-0626-LY2363)

Related Products

Human Recombinant HDAC11, Active protein, GST Tag (CAT#: V2LY-0526-LY4464)

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Rabbit Anti-HDAC11 Recombinant Antibody (D5I8E) (CAT#: CBMAB-CP0915-LY)

Rat Recombinant HDAC11, Active protein, GST Tag (CAT#: V2LY-0526-LY9411)

Cynomolgus Recombinant HDAC11, Active protein, GST Tag (CAT#: V2LY-0526-LY1528)

Mouse Anti-HDAC11 Recombinant Antibody (1C2-2G5) (CAT#: CBMAB-A3796-LY)

Mouse Recombinant HDAC11, Active protein, GST Tag (CAT#: V2LY-0526-LY8386)

Human HDAC11 ELISA Kit (CAT#: V2LY-0626-LY2363)

Mouse Anti-HDAC11 (AA 1-347) Monoclonal Antibody (CBFYH-3032) (CAT#: CBMAB-H1740-FY)

Mouse Anti-HDAC11 Recombinant Antibody (CBFYH-0828) (CAT#: CBMAB-H0662-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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