Mouse Anti-HDGFRP2 Antibody (3D1) (CBMAB-0452-YC)

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Basic Information

Host Animal
Mouse
Clone
3D1
Application
ELISA, IP
Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Hepatoma-derived growth factor-related protein 2
Introduction
HDGFRP2 (hepatoma-derived growth factor-related protein 2) is a member of the hepatoma-derived growth factor (HDGF) family. HDGFRP2 contains an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. HDGFRP2 functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection.
Entrez Gene ID
84717
UniProt ID
Q7Z4V5
Alternative Names
HRP2; HDGF2; HRP-2; HDGF-2; HDGFL2
Function
Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350).

Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350).

Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387).

Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350).

Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719).
Biological Process
Muscle cell differentiation Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of double-strand break repair via homologous recombination Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle tissue regeneration Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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