HDGFRP2

HDGFRP2 (hepatoma-derived growth factor-related protein 2) is a member of the hepatoma-derived growth factor (HDGF) family. HDGFRP2 contains an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. HDGFRP2 functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection.

Full Name

Hepatoma-derived growth factor-related protein 2

Function

Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350).

Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350).

Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387).

Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350).

Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719).

Biological Process

Muscle cell differentiation Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of double-strand break repair via homologous recombination Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle tissue regeneration Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm