Mouse Anti-HECTD2 (AA 331-441) Recombinant Antibody (CBFYH-0917) (CBMAB-H1850-FY)

Name: Mouse Anti-HECTD2 (AA 331-441) Recombinant Antibody (CBFYH-0917)
SKU: CBMAB-H1850-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-0917

Antibody Isotype

IgG2a, κ

Application

ELISA, IHC-P, WB

Basic Information

Immunogen

Recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 331-441

Target

Full Name

HECT domain containing 2

Introduction

HECTD2 (HECT Domain E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is UBE3A.

Entrez Gene ID

143279

UniProt ID

Q5U5R9

Alternative Names

HECT Domain E3 Ubiquitin Protein Ligase 2; HECT Domain Containing E3 Ubiquitin Protein Ligase 2; HECT-Type E3 Ubiquitin Transferase HECTD2; HECT Domain-Containing Protein 2; EC 2.3.2.26

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

(Microbial infection) Catalyzes ubiquitination of Botulinum neurotoxin A light chain (LC) of C.botulinum neurotoxin type A (BoNT/A).

Cellular Location

Cytosol

More Infomation

References

Ryu, T. Y., Kim, K., Han, T. S., Lee, M. O., Lee, J., Choi, J., ... & Cho, H. S. (2022). Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer. The ISME Journal, 16(5), 1205-1221.

Ma, L., Li, D. H., & Xu, Z. (2022). HECTD2 Represses Cell Proliferation in Colorectal Cancer through Driving Ubiquitination and Degradation of LPCAT1. Molecular Biology, 56(4), 533-542.

Ottina, E., Panova, V., Doglio, L., Kazachenka, A., Cornish, G., Kirkpatrick, J., ... & Kassiotis, G. (2021). E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion. Oncogene, 40(37), 5567-5578.

Lv, D., Shen, T., Yao, J., Yang, Q., Xiang, Y., & Ma, Z. (2021). HIF-1α induces HECTD2 up-regulation and aggravates the malignant progression of renal cell cancer via repressing miR-320a. Frontiers in Cell and Developmental Biology, 9, 775642.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-HECTD2 Recombinant Antibody (3D6)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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