Mouse Anti-HEYL Monoclonal Antibody (CBFYH-3055) (CBMAB-H1932-FY)

Name: Mouse Anti-HEYL Monoclonal Antibody (CBFYH-3055)
SKU: CBMAB-H1932-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-3055

Application

Dot

Immunogen

Recombinant human protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

HEYL

Introduction

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Entrez Gene ID

26508

UniProt ID

Q9NQ87

Alternative Names

Hes Related Family BHLH Transcription Factor With YRPW Motif-Like; Hairy/Enhancer-Of-Split Related With YRPW Motif 3; Class B Basic Helix-Loop-Helix Protein 33; Hairy-Related Transcription Factor 3; BHLHb33; HRT-3; HHRT3; HHeyL

Function

Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity).

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity).

Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Aortic valve morphogenesis Source: BHF-UCL
Atrioventricular valve morphogenesis Source: BHF-UCL
Cardiac epithelial to mesenchymal transition Source: BHF-UCL
Cardiac ventricle morphogenesis Source: BHF-UCL
Cellular response to BMP stimulus Source: Ensembl
Endocardial cushion morphogenesis Source: BHF-UCL
Epithelial to mesenchymal transition involved in endocardial cushion formation Source: UniProtKB
Glomerulus development Source: Ensembl
Mesenchymal cell development Source: BHF-UCL
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of DNA-binding transcription factor activity Source: UniProtKB
Negative regulation of gene expression Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Notch signaling involved in heart development Source: BHF-UCL
Notch signaling pathway Source: UniProtKB
Outflow tract morphogenesis Source: BHF-UCL
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Proximal tubule development Source: Ensembl
Pulmonary valve morphogenesis Source: BHF-UCL
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: Ensembl
Ventricular septum morphogenesis Source: BHF-UCL

Cellular Location

Nucleus

Liu, H., Ni, S., Wang, H., Zhang, Q., & Weng, W. (2020). Charactering tumor microenvironment reveals stromal‐related transcription factors promote tumor carcinogenesis in gastric cancer. Cancer medicine, 9(14), 5247-5257.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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