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HEYL

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq]
Full Name
HEYL
Function
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity).

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity).

Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Aortic valve morphogenesis Source: BHF-UCL
Atrioventricular valve morphogenesis Source: BHF-UCL
Cardiac epithelial to mesenchymal transition Source: BHF-UCL
Cardiac ventricle morphogenesis Source: BHF-UCL
Cellular response to BMP stimulus Source: Ensembl
Endocardial cushion morphogenesis Source: BHF-UCL
Epithelial to mesenchymal transition involved in endocardial cushion formation Source: UniProtKB
Glomerulus development Source: Ensembl
Mesenchymal cell development Source: BHF-UCL
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of DNA-binding transcription factor activity Source: UniProtKB
Negative regulation of gene expression Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Notch signaling involved in heart development Source: BHF-UCL
Notch signaling pathway Source: UniProtKB
Outflow tract morphogenesis Source: BHF-UCL
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Proximal tubule development Source: Ensembl
Pulmonary valve morphogenesis Source: BHF-UCL
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: Ensembl
Ventricular septum morphogenesis Source: BHF-UCL
Cellular Location
Nucleus
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Anti-HEYL antibodies

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Mouse Anti-HEYL Antibody (1G9) (CBMAB-0465-YC)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1G9
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-HEYL Recombinant Antibody (4A11) (CBMAB-A3873-LY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A11
Application*: WB, E
Datasheet SDS

Mouse Anti-HEYL Recombinant Antibody (2G1) (CBMAB-A3868-LY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2G1
Application*: IF, E
Datasheet SDS

Mouse Anti-HEYL Recombinant Antibody (1F6) (CBMAB-A3866-LY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1F6
Application*: WB, E
Datasheet SDS

Mouse Anti-HEYL Recombinant Antibody (2E12) (CBMAB-A3864-LY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E12
Application*: WB, E
Datasheet SDS

Mouse Anti-HEYL Recombinant Antibody (1E2) (CBMAB-A3863-LY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E2
Application*: WB, E
Datasheet SDS

Mouse Anti-HEYL Recombinant Antibody (CBFYH-0997) (CBMAB-H1938-FY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0997
Application*: WB
Datasheet SDS

Mouse Anti-HEYL (AA 221-327) Recombinant Antibody (CBFYH-0995) (CBMAB-H1936-FY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0995
Application*: E, WB
Datasheet SDS

Mouse Anti-HEYL (AA 1-70) Recombinant Antibody (CBFYH-0994) (CBMAB-H1935-FY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-0994
Application*: E, WB
Datasheet SDS

Mouse Anti-HEYL (AA 221-327) Recombinant Antibody (CBFYH-0993) (CBMAB-H1934-FY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-0993
Application*: E, IF
Datasheet SDS

Mouse Anti-HEYL (AA 221-327) Recombinant Antibody (CBFYH-0992) (CBMAB-H1933-FY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG, κ
Specificity: Human
Clone: CBFYH-0992
Application*: IF, WB
Datasheet SDS

Mouse Anti-HEYL Monoclonal Antibody (CBFYH-3055) (CBMAB-H1932-FY)

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Target: HEYL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3055
Application*: DB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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