HEYL

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq]

HEYL

Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity).

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity).

Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

Anterior/posterior pattern specification Source: GO_Central
Aortic valve morphogenesis Source: BHF-UCL
Atrioventricular valve morphogenesis Source: BHF-UCL
Cardiac epithelial to mesenchymal transition Source: BHF-UCL
Cardiac ventricle morphogenesis Source: BHF-UCL
Cellular response to BMP stimulus Source: Ensembl
Endocardial cushion morphogenesis Source: BHF-UCL
Epithelial to mesenchymal transition involved in endocardial cushion formation Source: UniProtKB
Glomerulus development Source: Ensembl
Mesenchymal cell development Source: BHF-UCL
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of DNA-binding transcription factor activity Source: UniProtKB
Negative regulation of gene expression Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Notch signaling involved in heart development Source: BHF-UCL
Notch signaling pathway Source: UniProtKB
Outflow tract morphogenesis Source: BHF-UCL
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Proximal tubule development Source: Ensembl
Pulmonary valve morphogenesis Source: BHF-UCL
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: Ensembl
Ventricular septum morphogenesis Source: BHF-UCL

Nucleus