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Mouse Anti-HEYL Antibody (1G9) (CBMAB-0465-YC)

Provided herein are mouse monoclonal antibodies against Human HEYL. The antibody clone 1G9 can be used for immunoassay techniques, such as IP, WB and MA.
See all HEYL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G9
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HEYL
Introduction
HEYL (hairy/ enhancer-of-split related with YRPW notif protein) is a member of the hairy and enhancer of split-related (HESR) family, which contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. HEYL is thought to be an effector of Notch signaling and a regulator of cell fate decisions.
Entrez Gene ID
26508
UniProt ID
Q9NQ87
Alternative Names
bHLHb33; HESR3; HEY3
Function
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity).

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity).

Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Aortic valve morphogenesis Source: BHF-UCL
Atrioventricular valve morphogenesis Source: BHF-UCL
Cardiac epithelial to mesenchymal transition Source: BHF-UCL
Cardiac ventricle morphogenesis Source: BHF-UCL
Cellular response to BMP stimulus Source: Ensembl
Endocardial cushion morphogenesis Source: BHF-UCL
Epithelial to mesenchymal transition involved in endocardial cushion formation Source: UniProtKB
Glomerulus development Source: Ensembl
Mesenchymal cell development Source: BHF-UCL
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of DNA-binding transcription factor activity Source: UniProtKB
Negative regulation of gene expression Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Notch signaling involved in heart development Source: BHF-UCL
Notch signaling pathway Source: UniProtKB
Outflow tract morphogenesis Source: BHF-UCL
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Proximal tubule development Source: Ensembl
Pulmonary valve morphogenesis Source: BHF-UCL
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle cell differentiation Source: Ensembl
Ventricular septum morphogenesis Source: BHF-UCL
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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