Mouse Anti-HILS1 Recombinant Antibody (CBFYH-1106) (CBMAB-H2057-FY)

Name: Mouse Anti-HILS1 Recombinant Antibody (CBFYH-1106)
SKU: CBMAB-H2057-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-1106

Application

ELISA, IF, WB

Immunogen

Nuclei from myeloid leukemia biopsy cells

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 40% glycerol

Preservative

0.1% Sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene)

Introduction

This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein.

Entrez Gene ID

373861

UniProt ID

P60008

Alternative Names

Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene); Spermatid-Specific Linker Histone H1-Like Protein; Histone Linker H1 Domain, Spermatid-Specific 1; H1.9

Function

DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

Biological Process

Chromatin remodeling Source: UniProtKB
Chromosome condensation Source: UniProtKB
Germ cell development Source: UniProtKB
Heterochromatin assembly Source: UniProtKB
Negative regulation of DNA recombination Source: GO_Central
Nucleosome assembly Source: InterPro
Nucleosome positioning Source: GO_Central
Regulation of transcription, DNA-templated Source: UniProtKB
Spermatogenesis Source: UniProtKB

Cellular Location

Nucleus; Chromosome

Mishra, L. N., Shalini, V., Gupta, N., Ghosh, K., Suthar, N., Bhaduri, U., & Rao, M. S. (2018). Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements. Epigenetics & chromatin, 11, 1-21.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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