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Mouse Anti-HIVEP2 Recombinant Antibody (CBXS-4283) (CBMAB-S1529-CQ)

This product is a mouse antibody that recognizes HIVEP2. The antibody CBXS-4283 can be used for immunoassay techniques such as: Dot, WB.
See all HIVEP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4283
Antibody Isotype
IgG1
Application
Dot, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Human Immunodeficiency Virus Type I Enhancer Binding Protein 2
Introduction
This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence.
Entrez Gene ID
3097
UniProt ID
P31629
Alternative Names
Human Immunodeficiency Virus Type I Enhancer Binding Protein 2; Human Immunodeficiency Virus Type I Enhancer-Binding Protein 2; C-Myc Intron Binding Protein 1; HIV-EP2; MBP-2; Transcription Factor HIVEP2; MHC Binding Protein-2; MHC-Binding Protein 2;
Function
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
Biological Process
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Mental retardation, autosomal dominant 43 (MRD43):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD43 patients manifest developmental delay, intellectual disability, hypotonia, and dysmorphic features.

Abreu, M., Branco, T., Figueiroa, S., & Reis, C. F. (2023). Parental gonadossomatic mosaicism in HIVEP2-related intellectual disability and impact on genetic counseling–case report. Frontiers in Genetics, 14.

van Mierlo, H. C., De Wit, L. E., van Griensven, J. M., & Lachmeijer, A. M. (2023). Successful Electroconvulsive Therapy in a Patient With Catatonia and a Rare HIVEP2 Mutation. The Journal of ECT, 10-1097.

Mo, A., Snyder, L. G., Babington, O., Chung, W. K., Sahin, M., & Srivastava, S. (2022). Neurodevelopmental profile of HIVEP2‐related disorder. Developmental Medicine & Child Neurology, 64(5), 654-661.

Quental, R., Borges, J. P., Santos, H., & Leão, M. (2022). Expanding the Phenotypic Spectrum of HIVEP2-Related Intellectual Disability: Description of Two Portuguese Patients and Review of the Literature. Molecular Syndromology, 13(5), 397-401.

Jain, A., & Atwal, P. S. (2019). Novel HIVEP2 variant p. Q1248* is associated with developmental delay: a case report. Journal of Pediatric Genetics, 8(03), 157-159.

Zhao, J., Chen, C., Bell, R. L., Qing, H., & Lin, Z. (2019). Identification of HIVEP2 as a dopaminergic transcription factor related to substance use disorders in rats and humans. Translational Psychiatry, 9(1), 247.

Modai, S., Farberov, L., Herzig, E., Isakov, O., Hizi, A., & Shomron, N. (2019). HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication. PLoS One, 14(1), e0211111.

Park, J., Colombo, R., Schäferhoff, K., Janiri, L., Grimmel, M., Sturm, M., ... & Kehrer, M. (2019). Novel HIVEP2 variants in patients with intellectual disability. Molecular Syndromology, 10(4), 195-201.

Goldsmith, H., Wells, A., Sá, M. J., Williams, M., Heussler, H., Buckman, M., ... & Goel, H. (2019). Expanding the phenotype of intellectual disability caused by HIVEP2 variants. American Journal of Medical Genetics Part A, 179(9), 1872-1877.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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