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Mouse Anti-HKDC1 (AA 1-427) Recombinant Antibody (CBFYH-1242) (CBMAB-H2214-FY)

This product is mouse antibody that recognizes HKDC1. The antibody CBFYH-1242 can be used for immunoassay techniques such as: ELISA, IP.
See all HKDC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1242
Antibody Isotype
IgG2a, κ
Application
ELISA, IP

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-427

Target

Full Name
hexokinase domain containing 1
Introduction
This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma.
Entrez Gene ID
80201
UniProt ID
Q2TB90
Alternative Names
Hexokinase Domain Containing 1; EC 2.7.1.1; Hexokinase Domain-Containing Protein 1; EC 2.7.
Function
Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (PubMed:30517626).

Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626).

Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity).
Biological Process
Cellular glucose homeostasis Source: UniProtKB
Glucose 6-phosphate metabolic process Source: UniProtKB
Glycolytic process Source: GO_Central
Hexose metabolic process Source: UniProtKB-UniPathway
Cellular Location
Mitochondrion membrane. The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion.

Jiang, H., Yao, Q., An, Y., Fan, L., Wang, J., & Li, H. (2022). Baicalin suppresses the progression of Type 2 diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1/clevaged Capase3 pathway. Phytomedicine, 94, 153823.

Guo, J., Ye, F., Xie, W., Zhang, X., Zeng, R., Sheng, W., ... & Sheng, X. (2022). The HOXC‐AS2/miR‐876‐5p/HKDC1 axis regulates endometrial cancer progression in a high glucose‐related tumor microenvironment. Cancer science, 113(7), 2297-2310.

Khan, M. W., Terry, A. R., Priyadarshini, M., Ilievski, V., Farooq, Z., Guzman, G., ... & Layden, B. T. (2022). The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression. Cell Death & Disease, 13(7), 660.

Wang, X., Shi, B., Zhao, Y., Lu, Q., Fei, X., Lu, C., ... & Chen, H. (2020). HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway. Cancer Cell International, 20, 1-12.

Pusec, C. M., De Jesus, A., Khan, M. W., Terry, A. R., Ludvik, A. E., Xu, K., ... & Layden, B. T. (2019). Hepatic HKDC1 expression contributes to liver metabolism. Endocrinology, 160(2), 313-330.

Khan, M. W., Priyadarshini, M., Cordoba-Chacon, J., Becker, T. C., & Layden, B. T. (2019). Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1865(3), 678-687.

Chen, X., Lv, Y., Sun, Y., Zhang, H., Xie, W., Zhong, L., ... & Yao, P. (2019). PGC1β regulates breast tumor growth and metastasis by SREBP1-mediated HKDC1 expression. Frontiers in oncology, 9, 290.

Fuhr, L., El-Athman, R., Scrima, R., Cela, O., Carbone, A., Knoop, H., ... & Relógio, A. (2018). The circadian clock regulates metabolic phenotype rewiring via HKDC1 and modulates tumor progression and drug response in colorectal cancer. EBioMedicine, 33, 105-121.

Zhang, L., Sun, Z., Zhao, P., Huang, L., Xu, M., Yang, Y., ... & Zhu, X. (2018). Whole-exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa. Human Molecular Genetics, 27(23), 4157-4168.

Evstafieva, A. G., Kovaleva, I. E., Shoshinova, M. S., Budanov, A. V., & Chumakov, P. M. (2018). Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response. PloS one, 13(2), e0191107.

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For research use only. Not intended for any clinical use.

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