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Mouse Anti-HLA-DMA Monoclonal Antibody (CBFYH-3099) (CBMAB-H0233-FY)

This product is mouse antibody that recognizes HLA-DMA. The antibody CBFYH-3099 can be used for immunoassay techniques such as: ICFC.
See all HLA-DMA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3099
Antibody Isotype
IgG1, κ
Application
ICFC

Basic Information

Immunogen
MHC class II enriched organelles from the B cell line Pala
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Major Histocompatibility Complex, Class II, DM Alpha
Introduction
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Entrez Gene ID
3108
UniProt ID
P28067
Alternative Names
Major Histocompatibility Complex, Class II, DM Alpha; Really Interesting New Gene 6 Protein; MHC Class II Antigen DMA; RING6; DMA; HLA Class II Histocompatibility Antigen, DM Alpha Chain; Class II Histocompatibility Antigen, M Alpha Chain; D6S222E; HLADM
Function
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: GO_Central
Peptide antigen assembly with MHC class II protein complex Source: UniProtKB
Positive regulation of T cell activation Source: GO_Central
Cellular Location
Lysosome membrane; Late endosome membrane. Localizes to late endocytic compartment. Associates with lysosome membranes.
Topology
Lumenal: 27-233
Helical: 234-254
Cytoplasmic: 255-261
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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