HLA-DMA

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Full Name
Major Histocompatibility Complex, Class II, DM Alpha
Function
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: GO_Central
Peptide antigen assembly with MHC class II protein complex Source: UniProtKB
Positive regulation of T cell activation Source: GO_Central
Cellular Location
Lysosome membrane; Late endosome membrane. Localizes to late endocytic compartment. Associates with lysosome membranes.
Topology
Lumenal: 27-233
Helical: 234-254
Cytoplasmic: 255-261
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Anti-HLA-DMA antibodies

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Mouse Anti-HLA-DMA (AA 1-262) Monoclonal Antibody (CBFYH-3100) (CBMAB-H2287-FY)

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Target: HLA-DMA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3100
Application*: WB
Datasheet SDS

HLA-DMA Matched Antibody Pair (545) (APMAB-545LY)

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Target: HLA-DMA
Specificity: Human
Datasheet SDS

Mouse Anti-HLA-DMA Recombinant Antibody (3F12-F11) (CBMAB-A3933-LY)

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Target: HLA-DMA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F12-F11
Application*: WB, E
Datasheet SDS

Mouse Anti-HLA-DMA Monoclonal Antibody (CBFYH-3102) (CBMAB-H2289-FY)

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Target: HLA-DMA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3102
Application*: WB, E, R, F
Datasheet SDS

Mouse Anti-HLA-DMA Monoclonal Antibody (CBFYH-3101) (CBMAB-H2288-FY)

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Target: HLA-DMA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3101
Application*: E, F, ID, WB
Datasheet SDS

Mouse Anti-HLA-DMA (AA 10-300) Recombinant Antibody (5C9NB) (CBMAB-H0523-FY)

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Target: HLA-DMA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5C9NB
Application*: WB, IH, IF, P, F
Datasheet SDS

Mouse Anti-HLA-DMA Monoclonal Antibody (CBFYH-3099) (CBMAB-H0233-FY)

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Target: HLA-DMA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3099
Application*: IS
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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