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Rabbit Anti-HLA-DOA Recombinant Antibody (EG1517) (CBMAB-EN1815-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1517
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human HLA-DOA.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Major Histocompatibility Complex, Class II, DO Alpha
Introduction
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3111
UniProt ID
P06340
Alternative Names
Major Histocompatibility Complex, Class II, DO Alpha; MHC Class II Antigen DOA; MHC DN-Alpha; MHC DZ Alpha; HLA-DNA; HLA-DZA;
Function
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: GO_Central
Negative regulation of antigen processing and presentation of peptide antigen via MHC class II Source: UniProtKB
Peptide antigen assembly with MHC class II protein complex Source: GO_Central
Positive regulation of T cell activation Source: GO_Central
Regulation of T cell differentiation Source: Ensembl
Cellular Location
Lysosome membrane; Endosome membrane. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Topology
Extracellular: 26-217
Helical: 218-240
Cytoplasmic: 241-250
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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