HLA-DOA

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

Full Name

Major Histocompatibility Complex, Class II, DO Alpha

Function

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: GO_Central
Negative regulation of antigen processing and presentation of peptide antigen via MHC class II Source: UniProtKB
Peptide antigen assembly with MHC class II protein complex Source: GO_Central
Positive regulation of T cell activation Source: GO_Central
Regulation of T cell differentiation Source: Ensembl

Cellular Location

Lysosome membrane; Endosome membrane. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Topology

Extracellular: 26-217
Helical: 218-240
Cytoplasmic: 241-250