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Mouse Anti-HLA-DOB Recombinant Antibody (DOB 10E6/5) (CBMAB-H0105-FY)

This product is mouse antibody that recognizes HLA-DOB. The antibody DOB 10E6/5 can be used for immunoassay techniques such as: WB, ELISA.
See all HLA-DOB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
DOB 10E6/5
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Immunogen
C-terminal peptide MHC class II
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Major Histocompatibility Complex, Class II, DO Beta
Introduction
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Entrez Gene ID
3112
UniProt ID
P13765
Alternative Names
Major Histocompatibility Complex, Class II, DO Beta; MHC Class II Antigen DOB; HLA Class II Histocompatibility Antigen, DO Beta Chain; HLA_DOB; DOB
Function
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: GO_Central
Negative regulation of antigen processing and presentation of peptide antigen via MHC class II Source: UniProtKB
Peptide antigen assembly with MHC class II protein complex Source: GO_Central
Positive regulation of T cell activation Source: GO_Central
Cellular Location
Lysosome membrane; Endosome membrane. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Topology
Extracellular: 27-224
Helical: 225-245
Cytoplasmic: 246-273
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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