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Rabbit Anti-HLA-DOB Recombinant Antibody (EG1518) (CBMAB-EN1816-LY)

The product is antibody recognizes HLA-DOB. The antibody EG1518 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all HLA-DOB antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1518
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from N-terminal of human HLA-DOB.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Major Histocompatibility Complex, Class II, DO Beta
Introduction
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3112
UniProt ID
P13765
Alternative Names
Major Histocompatibility Complex, Class II, DO Beta; MHC Class II Antigen DOB; HLA Class II Histocompatibility Antigen, DO Beta Chain; HLA_DOB; DOB;
Function
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: GO_Central
Negative regulation of antigen processing and presentation of peptide antigen via MHC class II Source: UniProtKB
Peptide antigen assembly with MHC class II protein complex Source: GO_Central
Positive regulation of T cell activation Source: GO_Central
Cellular Location
Lysosome membrane; Endosome membrane. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Topology
Extracellular: 27-224
Helical: 225-245
Cytoplasmic: 246-273
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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