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Mouse Anti-HLA-DQA1 Recombinant Antibody (1A3) (CBMAB-A3944-LY)

The product is antibody recognizes HLA-DQA1. The antibody 1A3 immunoassay techniques such as: WB, ELISA.
See all HLA-DQA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HLA-DQA1 (NP_002113.2, 24 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
major histocompatibility complex, class II, DQ alpha 1
Introduction
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq]
Entrez Gene ID
3117
UniProt ID
P01909
Alternative Names
CD; CELIAC1; DQ-A1; FLJ27088; FLJ27328; GSE; HLA-DQA; MGC149527
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Cellular Location
Lysosome membrane; Endosome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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