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Mouse Anti-HLF Antibody (1C5) (CBMAB-0474-YC)

Provided herein are mouse monoclonal antibodies against Human HLF. The antibody clone 1C5 can be used for immunoassay techniques, such as IP, WB and MA.
See all HLF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C5
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hepatic leukemia factor
Introduction
HLF (hepatic leukemia factor) is a member of the proline and acidic-rich (PAR) protein family, which forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of HLF with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias.
Entrez Gene ID
3131
UniProt ID
Q16534
Alternative Names
HLF, PAR bZIP transcription factor
Biological Process
Multicellular organism development Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Rhythmic process Source: UniProtKB-KW
Skeletal muscle cell differentiation Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

Li, M., Yao, T., Lin, W., Hinckley, W. E., Galli, M., Muchero, W., ... & Huang, S. S. C. (2023). Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors. Nature communications, 14(1), 2600.

Yang, Y., Yu, T. F., Ma, J., Chen, J., Zhou, Y. B., Chen, M., ... & Xu, Z. S. (2020). The soybean bZIP transcription factor gene GmbZIP2 confers drought and salt resistances in transgenic plants. International journal of molecular sciences, 21(2), 670.

Rambousek, L., Gschwind, T., Lafourcade, C., Paterna, J. C., Dib, L., Fritschy, J. M., & Fontana, A. (2020). Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor. Scientific reports, 10(1), 3760.

Chen, J., Liu, A., Lin, Z., Wang, B., Chai, X., Chen, S., ... & Huang, Y. (2020). Downregulation of the circadian rhythm regulator HLF promotes multiple-organ distant metastases in non-small cell lung cancer through PPAR/NF-κb signaling. Cancer Letters, 482, 56-71.

Michael, R., Ranjan, A., Kumar, R. S., Pathak, P. K., & Trivedi, P. K. (2020). Light-regulated expression of terpene synthase gene, AtTPS03, is controlled by the bZIP transcription factor, HY5, in Arabidopsis thaliana. Biochemical and Biophysical Research Communications, 529(2), 437-443.

Xiang, D. M., Sun, W., Ning, B. F., Zhou, T. F., Li, X. F., Zhong, W., ... & Ding, J. (2018). The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis. Gut, 67(9), 1704-1715.

Suzuki, K., Yoshida, K., Ueha, T., Kaneshiro, K., Nakai, A., Hashimoto, N., ... & Hashiramoto, A. (2018). Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts. Arthritis Research & Therapy, 20, 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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