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HLF

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]

Full Name

hepatic leukemia factor

Biological Process

Multicellular organism development Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Rhythmic process Source: UniProtKB-KW
Skeletal muscle cell differentiation Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

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Anti-HLF antibodies

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Mouse Anti-HLF Antibody (1C5) (CBMAB-0474-YC)

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Target: HLF

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1C5

Application*: IP, WB, M

Mouse Anti-HLF Recombinant Antibody (2C9) (CBMAB-A3948-LY)

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Target: HLF

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2C9

Application*: WB, E

Mouse Anti-HLF Recombinant Antibody (1F12-1C4) (CBMAB-A3947-LY)

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Target: HLF

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1F12-1C4

Application*: WB, E

Mouse Anti-HLF (AA 1-296) Recombinant Antibody (CBFYH-1482) (CBMAB-H2437-FY)

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Target: HLF

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-1482

Application*: E, IF, WB

Mouse Anti-HLF Recombinant Antibody (CBFYH-1480) (CBMAB-H2435-FY)

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Target: HLF

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-1480

Application*: WB, E, IF

Mouse Anti-HLF Monoclonal Antibody (CBFYH-3154) (CBMAB-H2434-FY)

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Target: HLF

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYH-3154

Application*: IP, WB

Mouse Anti-HLF (AA 1-296) Monoclonal Antibody (CBFYH-3153) (CBMAB-H2433-FY)

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Target: HLF

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-3153

Application*: WB

Mouse Anti-HLF Recombinant Antibody (CBFYH-1479) (CBMAB-H0708-FY)

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Target: HLF

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-1479

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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