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Rabbit Anti-HMGN2 Recombinant Antibody (EG1523) (CBMAB-EN1822-LY)

The product is antibody recognizes HMG17. The antibody EG1523 immunoassay techniques such as: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000.
See all HMGN2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1523
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from Internal of human HMG17.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
high mobility group nucleosomal binding domain 2
Introduction
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi.
Entrez Gene ID
Human3151
Mouse15331
Rat114637
UniProt ID
HumanP05204
MouseP09602
RatP18437
Alternative Names
HMG17
Function
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Chromatin organization Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
PTM
Phosphorylation favors cytoplasmic localization.

Eliason, S., Su, D., Pinho, F., Sun, Z., Zhang, Z., Li, X., ... & Amendt, B. A. (2022). HMGN2 represses gene transcription via interaction with transcription factors Lef-1 and Pitx2 during amelogenesis. Journal of Biological Chemistry, 298(9).

Jing, Y., Tian, G., Qin, X., Liu, Z., & Li, X. D. (2021). Lysine succinylation on non-histone chromosomal protein HMG-17 (HMGN2) regulates nucleosomal DNA accessibility by disrupting the HMGN2–nucleosome association. RSC Chemical Biology, 2(4), 1257-1262.

Craig, J. M., Turner, T. H., Harrell, J. C., & Clevenger, C. V. (2021). Prolactin drives a dynamic STAT5A/HDAC6/HMGN2 cis-regulatory landscape exploitable in ER+ breast cancer. Endocrinology, 162(5), bqab036.

Du, Y., Guo, H., Guo, L., Miao, J., Ren, H., Liu, K., ... & Huang, N. (2021). The regulatory effect of acetylation of HMGN2 and H3K27 on pyocyanin‐induced autophagy in macrophages by affecting Ulk1 transcription. Journal of Cellular and Molecular Medicine, 25(15), 7524-7537.

Apelt, K., Zoutendijk, I., Gout, D. Y., Wondergem, A. P., van den Heuvel, D., & Luijsterburg, M. S. (2020). Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair. Scientific reports, 10(1), 4332.

Fan, B., Shi, S., Shen, X., Yang, X., Liu, N., Wu, G., ... & Huang, N. (2019). Effect of HMGN2 on proliferation and apoptosis of MCF-7 breast cancer cells. Oncology letters, 17(1), 1160-1166.

Garza-Manero, S., Sindi, A. A. A., Mohan, G., Rehbini, O., Jeantet, V. H., Bailo, M., ... & West, K. L. (2019). Maintenance of active chromatin states by HMGN2 is required for stem cell identity in a pluripotent stem cell model. Epigenetics & chromatin, 12(1), 1-18.

Wang, X., Chen, S., Ren, H., Chen, J., Li, J., Wang, Y., ... & Huang, N. (2019). HMGN2 regulates non‐tuberculous mycobacteria survival via modulation of M1 macrophage polarization. Journal of Cellular and Molecular Medicine, 23(12), 7985-7998.

Chen, J., Fan, Y., Cui, B., Li, X., Yu, Y., Du, Y., ... & Zhang, P. (2018). HMGN2: An antitumor effector molecule of γδT cells. Journal of Immunotherapy, 41(3), 118-124.

Li, D. D., Yue, L., Yang, Z. Q., Zheng, L. W., & Guo, B. (2018). Evidence for Hmgn2 involvement in mouse embryo implantation and decidualization. Cellular Physiology and Biochemistry, 44(5), 1681-1695.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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