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HMGN2

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi.

Full Name

high mobility group nucleosomal binding domain 2

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Chromatin organization Source: GO_Central
Killing of cells of other organism Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.

PTM

Phosphorylation favors cytoplasmic localization.

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Anti-HMGN2 antibodies

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Rabbit Anti-HMGN2 Recombinant Antibody (EG1523) (CBMAB-EN1822-LY)

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Target: HMGN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1523

Application*: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000

Rabbit Anti-HMGN2 Recombinant Antibody (D9B9) (CBMAB-H2529-FY)

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Target: HMGN2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Cattle, Dog, Pig, Guinea pig, Horse

Clone: D9B9

Application*: WB, IP, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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