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Mouse Anti-HMG20A Monoclonal Antibody (CBFYH-3157) (CBMAB-H2449-FY)

This product is mouse antibody that recognizes HMG20A. The antibody CBFYH-3157 can be used for immunoassay techniques such as: Dot.
See all HMG20A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3157
Antibody Isotype
IgG2b
Application
Dot

Basic Information

Immunogen
HMG20 A antibody was raised in mouse using recombinant Human High-Mobility Group 20
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
high-mobility group 20A
Introduction
HMG20A (High Mobility Group 20A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is HMG20B.
Entrez Gene ID
10363
UniProt ID
Q9NP66
Alternative Names
High Mobility Group 20A; HMG Domain-Containing Protein HMGX1; HMG Domain-Containing Protein 1; HMG Box-Containing Protein 20A; HMG Box Domain Containing 1; HMGXB1; HMGX1; High Mobility Group Protein 20A; High-Mobility Group 20A
Function
Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).
Biological Process
Chromatin organization Source: UniProtKB
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of protein sumoylation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of gene expression Source: GO_Central
Regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Nucleus

Zhang, T., Zhang, Y., Li, S., Ge, H., Song, Q., Zhang, Y., ... & Li, A. (2023). Gentianella acuta-derived Gen-miR-1 Suppresses Myocardial Fibrosis by Targeting HAX1/HMG20A/Smads Axis to Attenuate Inflammation in Cardiac Fibroblasts. Phytomedicine, 154923.

Herchenröther, A., Gossen, S., Friedrich, T., Reim, A., Daus, N., Diegmüller, F., ... & Hake, S. B. (2023). The H2A. Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs. Nature Communications, 14(1), 472.

Gómez-Marín, E., Posavec-Marjanović, M., Zarzuela, L., Basurto-Cayuela, L., Guerrero-Martínez, J. A., Arribas, G., ... & Reyes, J. C. (2022). The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways. Nucleic Acids Research, 50(17), 9838-9857.

Li, R., Meng, S., Ji, M., Rong, X., You, Z., Cai, C., ... & Yang, Y. (2022). HMG20A inhibit adipogenesis by transcriptional and epigenetic regulation of MEF2C expression. International Journal of Molecular Sciences, 23(18), 10559.

Pan, R., Yu, D., Hu, J., Yang, X., Wang, C., Zhang, L., ... & Cai, W. (2022). SFMBT1 facilitates colon cancer cell metastasis and drug resistance combined with HMG20A. Cell Death Discovery, 8(1), 263.

Lorenzo, P. I., Vazquez, E. M., López-Noriega, L., Fuente-Martín, E., Mellado-Gil, J. M., Franco, J. M., ... & Gauthier, B. R. (2021). The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity. Theranostics, 11(14), 6983.

Zhang, Z., Niu, J., Li, Q., Huang, Y., Jiang, B., Wu, Y., ... & Jian, J. (2021). HMG20A from Nile tilapia (Oreochromis niloticus) involved in the immune response to bacterial infection. Fish & Shellfish Immunology, 119, 499-507.

Huang, T., Wang, L., Bai, M., Zheng, J., Yuan, D., He, Y., ... & Cui, W. (2020). Influence of IGF2BP2, HMG20A, and HNF1B genetic polymorphisms on the susceptibility to Type 2 diabetes mellitus in Chinese Han population. Bioscience reports, 40(5), BSR20193955.

Mellado-Gil, J. M., Fuente-Martín, E., Lorenzo, P. I., Cobo-Vuilleumier, N., López-Noriega, L., Martín-Montalvo, A., ... & Gauthier, B. R. (2018). The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity. Cell Death & Disease, 9(3), 279.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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