Mouse Anti-HMGB2 Recombinant Antibody (4G7) (CBMAB-A3972-LY)

Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity).
Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity).
In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285).
Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675).
Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity).
Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity).
Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
Cellular response to lipopolysaccharide Source: UniProtKB
Chromatin organization Source: UniProtKB
Defense response to Gram-negative bacterium Source: AgBase
Defense response to Gram-positive bacterium Source: AgBase
DNA geometric change Source: AgBase
DNA topological change Source: UniProtKB
Double-strand break repair via nonhomologous end joining Source: UniProtKB
Inflammatory response to antigenic stimulus Source: AgBase
Innate immune response Source: UniProtKB-KW
Male gonad development Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Negative regulation of gene expression Source: Ensembl
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Nucleosome assembly Source: UniProtKB
Positive regulation of DNA binding Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of erythrocyte differentiation Source: UniProtKB
Positive regulation of innate immune response Source: Ensembl
Positive regulation of interferon-beta production Source: Ensembl
Positive regulation of megakaryocyte differentiation Source: UniProtKB
Positive regulation of nuclease activity Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of neurogenesis Source: AgBase
Regulation of stem cell proliferation Source: AgBase
Regulation of transcription by RNA polymerase II Source: UniProtKB
Response to lipopolysaccharide Source: AgBase
Response to steroid hormone Source: Ensembl
Spermatid nucleus differentiation Source: Ensembl
V(D)J recombination Source: UniProtKB
Acetylation enhances nucleosome binding and chromation remodeling activity.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Antibody Pairs
HMGB2 Matched Antibody Pair (555) (CAT#: APMAB-555LY)
HMGB2 Matched Antibody Pair (557) (CAT#: APMAB-557LY)
HMGB2 Matched Antibody Pair (558) (CAT#: APMAB-558LY)
HMGB2 Matched Antibody Pair (559) (CAT#: APMAB-559LY)
Related Products
HMGB2 Matched Antibody Pair (559) (CAT#: APMAB-559LY)
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Mouse Anti-HMGB2 Recombinant Antibody (CBFYH-1537) (CAT#: CBMAB-H2510-FY)
Mouse Anti-HMGB2 Recombinant Antibody (3E5) (CAT#: CBMAB-A3968-LY)
HMGB2 Matched Antibody Pair (557) (CAT#: APMAB-557LY)
HMGB2 Matched Antibody Pair (558) (CAT#: APMAB-558LY)
HMGB2 Matched Antibody Pair (556) (CAT#: APMAB-556LY)
Mouse Anti-HMGB2 Recombinant Antibody (X1) (CAT#: CBMAB-A3973-LY)
Rabbit Anti-HMGB2 Recombinant Antibody (EG1525) (CAT#: CBMAB-EN1824-LY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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