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Mouse Anti-HNRNPLL Monoclonal Antibody (CBFYH-3184) (CBMAB-H2669-FY)

This product is mouse antibody that recognizes HNRNPLL. The antibody CBFYH-3184 can be used for immunoassay techniques such as: Dot.
See all HNRNPLL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3184
Antibody Isotype
IgG2b
Application
Dot

Basic Information

Immunogen
HNRPLL antibody was raised in mouse using recombinant Human Heterogeneous Nuclear Ribonucleoprotein L-Like
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
heterogeneous nuclear ribonucleoprotein L-like
Introduction
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).
Entrez Gene ID
92906
UniProt ID
Q8WVV9
Alternative Names
Heterogeneous Nuclear Ribonucleoprotein L Like; HNRPLL; SRRF; Heterogeneous Nuclear Ribonucleoprotein L-Like; Stromal RNA Regulating Factor; Stromal RNA-Regulating Factor; HnRNPLL
Function
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
Biological Process
mRNA processing Source: InterPro
Positive regulation of RNA splicing Source: UniProtKB
Regulation of RNA splicing Source: GO_Central
Cellular Location
Nucleus; Membrane

Peng, S., He, T., Liu, Y., Zheng, L., Zhong, Y., Niu, Z., ... & Yang, S. (2023). Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs. Stem Cell Reviews and Reports, 1-13.

Mo, J., Wang, X., Xu, L., Chen, M., & Zhang, Q. (2023). HNRNPLL is a Prognostic Biomarker Associated with Hepatocellular Carcinoma Immune Infiltration and Related to Migration of Hepatocellular Carcinoma Cells.

Wang, X., Ping, C., Tan, P., Sun, C., Liu, G., Liu, T., ... & Huang, Y. (2021). hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal, 40(4), e104729.

Yabas, M., Yazicioglu, Y. F., Hoyne, G. F., Goodnow, C. C., & Enders, A. (2021). Loss of hnRNPLL‐dependent splicing of Ptprc has no impact on B‐cell development, activation and terminal differentiation into antibody‐secreting cells. Immunology and Cell Biology, 99(5), 532-541.

van den Buuse, M., Halley, P., & Hoyne, G. F. (2021). Behavioural phenotyping of thunder mice with a hypomorphic mutation of heterogeneous nuclear ribonuclear protein L-like (hnRNPLL) and reduced T cell function. Neuroscience Letters, 740, 135469.

Aoki, M., Sasaki, E., Kimura, K., Komori, K., Shimizu, Y., Yatabe, Y., & Sakuma, K. (2018). Identification of HNRNPLL as a novel metastasis suppressor of colorectal cancer. Cancer Research, 78(13_Supplement), 84-84.

Sakuma, K., Sasaki, E., Kimura, K., Komori, K., Shimizu, Y., Yatabe, Y., & Aoki, M. (2018). HNRNPLL stabilizes mRNA for DNA replication proteins and promotes cell cycle progression in colorectal cancer cells. Cancer science, 109(8), 2458-2468.

Sakuma, K., Sasaki, E., Kimura, K., Komori, K., Shimizu, Y., Yatabe, Y., & Aoki, M. (2018). HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition. Gut, 67(6), 1103-1111.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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