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HNRNPLL

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).

Full Name

heterogeneous nuclear ribonucleoprotein L-like

Function

RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.

Biological Process

mRNA processing Source: InterPro
Positive regulation of RNA splicing Source: UniProtKB
Regulation of RNA splicing Source: GO_Central

Cellular Location

Nucleus; Membrane

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Anti-HNRNPLL antibodies

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Mouse Anti-HNRNPLL (N-terminus) Recombinant Antibody (CBFYH-1665) (CBMAB-H2671-FY)

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Target: HNRNPLL

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYH-1665

Application*: WB

Mouse Anti-HNRNPLL Monoclonal Antibody (CBFYH-3184) (CBMAB-H2669-FY)

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Target: HNRNPLL

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYH-3184

Application*: DB

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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