Mouse Anti-HOOK2 Recombinant Antibody (CBFYH-1701) (CBMAB-H0712-FY)

Name: Mouse Anti-HOOK2 Recombinant Antibody (CBFYH-1701)
SKU: CBMAB-H0712-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-1701

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

hook homolog 2 (Drosophila)

Introduction

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.

Entrez Gene ID

29911

UniProt ID

Q96ED9

Alternative Names

Hook Microtubule Tethering Protein 2; H-Hook2; HHK2; Hook Homolog 2 (Drosophila); Protein Hook Homolog 2; Hook Homolog 2; HK2

Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997).

Biological Process

Cytoplasmic microtubule organization Source: GO_Central
Cytoskeleton-dependent intracellular transport Source: GO_Central
Early endosome to late endosome transport Source: UniProtKB
Endocytosis Source: ProtInc
Endosome organization Source: UniProtKB
Endosome to lysosome transport Source: UniProtKB
Lysosome organization Source: UniProtKB
Protein localization to perinuclear region of cytoplasm Source: UniProtKB
Protein transport Source: UniProtKB-KW

Cellular Location

Centrosome; Cytoskeleton; Cytoplasm; Trans-Golgi network. Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036). Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036, PubMed:32073997). Often found in close association with microtubules (PubMed:17540036). Localizes to the manchette in elongating spermatids (By similarity).

Knolle, C. (2022). Untersuchung der Genexpression von ACTN3, HOOK2, BRCA1 und BRCA2 im sporadischen Ovarialkarzinom unter Berücksichtigung klinischer Parameter (Doctoral dissertation).

Qiao, C., Jia, H., Zhang, H., Wang, H., Liang, J., Song, J., ... & Hu, J. (2020). Coding variants in HOOK2 and GTPBP3 may contribute to risk of primary angle closure glaucoma. DNA and Cell Biology, 39(6), 949-957.

Dwivedi, D., Kumari, A., Rathi, S., Mylavarapu, S. V., & Sharma, M. (2019). The dynein adaptor Hook2 plays essential roles in mitotic progression and cytokinesis. Journal of Cell Biology, 218(3), 871-894.

Dwivedi, D., & Sharma, M. (2019). HOOK2 mediates dynein-dynactin association to regulate mitotic progression and cytokinesis (Doctoral dissertation, IISERM).

Barthelemy-Requin, M., Massey-Harroche, D., Audebert, S., Borg, J. P., Wijnholds, J., & Le Bivic, A. (2019). CRB2 controls primary ciliogenesis in association with PAR6α, HOOK2 and RAB8A. bioRxiv, 830166.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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