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Mouse Anti-HOOK2 Recombinant Antibody (CBFYH-1705) (CBMAB-H2710-FY)

This product is mouse antibody that recognizes HOOK2. The antibody CBFYH-1705 can be used for immunoassay techniques such as: WB.
See all HOOK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1705
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hook homolog 2 (Drosophila)
Introduction
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.
Entrez Gene ID
29911
UniProt ID
Q96ED9
Alternative Names
Hook Microtubule Tethering Protein 2; H-Hook2; HHK2; Hook Homolog 2 (Drosophila); Protein Hook Homolog 2; Hook Homolog 2; HK2
Function
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997).
Biological Process
Cytoplasmic microtubule organization Source: GO_Central
Cytoskeleton-dependent intracellular transport Source: GO_Central
Early endosome to late endosome transport Source: UniProtKB
Endocytosis Source: ProtInc
Endosome organization Source: UniProtKB
Endosome to lysosome transport Source: UniProtKB
Lysosome organization Source: UniProtKB
Protein localization to perinuclear region of cytoplasm Source: UniProtKB
Protein transport Source: UniProtKB-KW
Cellular Location
Centrosome; Cytoskeleton; Cytoplasm; Trans-Golgi network. Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036). Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036, PubMed:32073997). Often found in close association with microtubules (PubMed:17540036). Localizes to the manchette in elongating spermatids (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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