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Rabbit Anti-HOPX Recombinant Antibody (D6E3) (CBMAB-CP1058-LY)

The product is antibody recognizes HOP. The antibody D6E3 immunoassay techniques such as: WB.
See all HOPX antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Hamster, Cattle
Clone
D6E3
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys513 of human HOP protein.
Specificity
Human, Mouse, Rat, Monkey, Hamster, Cattle
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
HOPX
Entrez Gene ID
Human84525
Mouse74318
Rat171160
Monkey694219
Hamster101840480
Cattle281270
UniProt ID
HumanQ9BPY8
MouseQ8R1H0
RatQ78ZR5
MonkeyI7GIM6
HamsterA0A1U7QKE3
CattleQ8MJD5
Function
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity).

May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).
Biological Process
Bundle of His development Source: BHF-UCL
Chaperone-mediated protein complex assembly Source: CAFA
Histone deacetylation Source: Ensembl
Lung alveolus development Source: Ensembl
Negative regulation of cell differentiation Source: MGI
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of skeletal muscle tissue regeneration Source: Ensembl
Positive regulation of striated muscle cell differentiation Source: Ensembl
Regulation of heart contraction Source: Ensembl
Regulation of protein binding Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Trophectodermal cell differentiation Source: MGI
Cellular Location
Nucleus; Cytoplasm

Caspa Gokulan, R., Yap, L. F., & Paterson, I. C. (2022). HOPX: A Unique Homeodomain Protein in Development and Tumor Suppression. Cancers, 14(11), 2764.

He, S., Ding, Y., Ji, Z., Yuan, B., Chen, J., & Ren, W. (2023). HOPX is a tumor-suppressive biomarker that corresponds to T cell infiltration in skin cutaneous melanoma. Cancer Cell International, 23(1), 1-16.

Hng, C. H., Camp, E., Anderson, P., Breen, J., Zannettino, A., & Gronthos, S. (2020). HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways. Scientific reports, 10(1), 11345.

Liu, Y., & Zhang, W. (2020). The role of HOPX in normal tissues and tumor progression. Bioscience reports, 40(1), BSR20191953.

Lin, C. C., Yao, C. Y., Hsu, Y. C., Hou, H. A., Yuan, C. T., Li, Y. H., ... & Tien, H. F. (2020). Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice. Oncogene, 39(28), 5112-5123.

Liang, H., Wang, C., Gao, K., Li, J., & Jia, R. (2019). ΜicroRNA‑421 promotes the progression of non‑small cell lung cancer by targeting HOPX and regulating the Wnt/β‑catenin signaling pathway. Molecular Medicine Reports, 20(1), 151-161.

Ota, C., Ng-Blichfeldt, J. P., Korfei, M., Alsafadi, H. N., Lehmann, M., Skronska-Wasek, W., ... & Königshoff, M. (2018). Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis. Scientific reports, 8(1), 12983.

Vaid, S., Camp, J. G., Hersemann, L., Eugster Oegema, C., Heninger, A. K., Winkler, S., ... & Namba, T. (2018). A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex. Development, 145(20), dev169276.

Friedman, C. E., Nguyen, Q., Lukowski, S. W., Helfer, A., Chiu, H. S., Miklas, J., ... & Palpant, N. J. (2018). Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation. Cell stem cell, 23(4), 586-598.

Zweifel, S., Marcy, G., Guidice, Q. L., Li, D., Heinrich, C., Azim, K., & Raineteau, O. (2018). HOPX defines heterogeneity of postnatal subventricular zone neural stem cells. Stem cell reports, 11(3), 770-783.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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