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Mouse Anti-HOXA10 Recombinant Antibody (CBFYH-1727) (CBMAB-H2730-FY)

This product is mouse antibody that recognizes HOXA10. The antibody CBFYH-1727 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all HOXA10 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYH-1727
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HOMEOBOX A10
Introduction
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene.
Entrez Gene ID
Human3206
Mouse15395
Rat103692129
UniProt ID
HumanP31260
MouseP31310
RatA0A0G2JWY7
Alternative Names
Homeobox A10; Homeobox Protein Hox-1.8; Homeobox Protein Hox-1H; Homeo Box A10; HOX1H; PL
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
Biological Process
Anterior/posterior pattern specification Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Male gonad development Source: Ensembl
Multicellular organism development Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Prostate gland development Source: Ensembl
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estrogen Source: Ensembl
Response to testosterone Source: Ensembl
Single fertilization Source: Ensembl
Skeletal system development Source: Ensembl
Spermatogenesis Source: ProtInc
Uterus development Source: Ensembl
Cellular Location
Nucleus

Ekanayake, D. L., Małopolska, M. M., Schwarz, T., Tuz, R., & Bartlewski, P. M. (2022). The roles and expression of HOXA/Hoxa10 gene: A prospective marker of mammalian female fertility?. Reproductive Biology, 22(2), 100647.

Nie, S., Zhang, L., Liu, J., Wan, Y., Jiang, Y., Yang, J., ... & Cheng, W. (2021). ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer. Journal of Experimental & Clinical Cancer Research, 40, 1-18.

Li, H., You, J., Xue, H., Tan, X., & Chao, C. (2020). CircCTDP1 promotes nasopharyngeal carcinoma progression via a microRNA‑320b/HOXA10/TGFβ2 pathway. International journal of molecular medicine, 45(3), 836-846.

Guo, C., Ju, Q. Q., Zhang, C. X., Gong, M., Li, Z. L., & Gao, Y. Y. (2020). Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemia. BMC cancer, 20, 1-12.

Yan, X., Cong, B., Chen, Q., Liu, L., Luan, X., Du, J., & Cao, M. (2020). Silencing lncRNA HOXA10-AS decreases cell proliferation of oral cancer and HOXA10-antisense RNA can serve as a novel prognostic predictor. Journal of International Medical Research, 48(8), 0300060520934254.

Hatanaka, Y., de Velasco, M. A., Oki, T., Shimizu, N., Nozawa, M., Yoshimura, K., ... & Uemura, H. (2019). HOXA10 expression profiling in prostate cancer. The Prostate, 79(5), 554-563.

Song, C., Han, Y., Luo, H., Qin, Z., Chen, Z., Liu, Y., ... & Zhou, C. (2019). HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer. Cancer Medicine, 8(12), 5651-5661.

Chen, W., Wu, G., Zhu, Y., Zhang, W., Zhang, H., Zhou, Y., & Sun, P. (2019). HOXA10 deteriorates gastric cancer through activating JAK1/STAT3 signaling pathway. Cancer management and research, 6625-6635.

Shao, M., Yang, Q., Zhu, W., Jin, H., Wang, J., Song, J., ... & Lv, X. (2018). LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation. Molecular Cancer, 17(1), 1-12.

Guo, L. M., Ding, G. F., Xu, W., Ge, H., Jiang, Y., Chen, X. J., & Lu, Y. (2018). MiR-135a-5p represses proliferation of HNSCC by targeting HOXA10. Cancer Biology & Therapy, 19(11), 973-983.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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