Mouse Anti-HOXA3 Monoclonal Antibody (CBFYH-3187) (CBMAB-H2738-FY)

Name: Mouse Anti-HOXA3 Monoclonal Antibody (CBFYH-3187)
SKU: CBMAB-H2738-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-3187

Application

Dot, ICC, IF

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

HOMEOBOX A3

Introduction

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.

Entrez Gene ID

3200

UniProt ID

O43365

Alternative Names

Homeobox A3; Homeobox Protein Hox-1E; Homeo Box A3; HOX1E; Homeobox Protein Hox-A3; Hox-1.5-Like Protein; Homeo Box 1E; HOX1

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Angiogenesis Source: UniProtKB
Animal organ formation Source: Ensembl
Anterior/posterior pattern specification Source: GO_Central
Blood vessel remodeling Source: Ensembl
Cartilage development Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Gene expression Source: Ensembl
Glossopharyngeal nerve morphogenesis Source: Ensembl
Parathyroid gland development Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Specification of animal organ position Source: Ensembl
Thymus development Source: Ensembl
Thyroid gland development Source: Ensembl

Cellular Location

Nucleus

Lu, H., Zhang, Q., Sun, Y., Wu, D., & Liu, L. (2020). LINC00689 induces gastric cancer progression via modulating the miR‐338‐3p/HOXA3 axis. The journal of gene medicine, 22(12), e3275.

Li, Z., Xu, H., Liu, X., Hong, Y., Lou, H., Liu, H., ... & Zhang, Y. (2020). GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3. Cell death & disease, 11(10), 917.

Lin, S., Zhang, R., An, X., Li, Z., Fang, C., Pan, B., ... & Han, W. (2019). LncRNA HOXA-AS3 confers cisplatin resistance by interacting with HOXA3 in non-small-cell lung carcinoma cells. Oncogenesis, 8(11), 60.

Jiang, L., Wu, Z., Meng, X., Chu, X., Huang, H., & Xu, C. (2019). LncRNA HOXA-AS2 facilitates tumorigenesis and progression of papillary thyroid cancer by modulating the miR-15a-5p/HOXA3 axis. Human gene therapy, 30(5), 618-631.

Zhao, Q., Zhao, S., Li, J., Zhang, H., Qian, C., Wang, H., ... & Zhao, Y. (2019). TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway. Biomedicine & Pharmacotherapy, 109, 1640-1649.

He, C., Chen, Z. Y., Li, Y., Yang, Z. Q., Zeng, F., Cui, Y., ... & Chen, H. Q. (2019). miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma. BMC nephrology, 20, 1-10.

Alrdahe, S., Al Sadoun, H., Torbica, T., McKenzie, E. A., Bowling, F. L., Boulton, A. J., & Mace, K. A. (2019). Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction. PLoS One, 14(10), e0223980.

Gordon, J. (2018). Hox genes in the pharyngeal region: how Hoxa3 controls early embryonic development of the pharyngeal organs. International Journal of Developmental Biology, 62(11-12), 775-783.

Gan, B. L., He, R. Q., Zhang, Y., Wei, D. M., Hu, X. H., & Chen, G. (2018). Downregulation of HOXA3 in lung adenocarcinoma and its relevant molecular mechanism analysed by RT-qPCR, TCGA and in silico analysis. International Journal of Oncology, 53(4), 1557-1579.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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