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Mouse Anti-HOXA6 Recombinant Antibody (3A6) (CBMAB-A4030-LY)

The product is antibody recognizes HOXA6. The antibody 3A6 immunoassay techniques such as: WB, ELISA.
See all HOXA6 antibodies
Published Data
Fig.1 Western blot analysis confirmed expression of the HOXA6-V5 and HOXA9-V5 tagged proteins.
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Fig.2. Increased proliferation of Ba/F3-A6, Mix-A6 and Mix-A9 cells.
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Fig.3 Differentiation of Mix-A6 and Mix-A9 in liquid culture.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3A6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXA6 (NP_076919, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homeobox A6
Introduction
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq]
Entrez Gene ID
3203
UniProt ID
P31267
Alternative Names
HOX1; HOX1.2; HOX1B
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Xiulin, J., Wang, C., Guo, J., Wang, C., Pan, C., & Nie, Z. (2022). Next-generation sequencing identifies HOXA6 as a novel oncogenic gene in low grade glioma. Aging (Albany NY), 14(6), 2819.

Lin, J., Zhu, H., Hong, L., Tang, W., Wang, J., Hu, H., ... & Liu, S. (2021). Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer. Aging (Albany NY), 13(5), 6606.

Deng, J., Ding, H. H., Long, J. L., Lin, S. Y., Liu, M., Zhang, X. Q., ... & Ruan, X. (2020). Oxaliplatin‐induced neuropathic pain involves HOXA6 via a TET1‐dependent demethylation of the SOX10 promoter. International Journal of Cancer, 147(9), 2503-2514.

Saijo, S., Kuwano, Y., Tange, S., Rokutan, K., & Nishida, K. (2019). A novel long non-coding RNA from the HOXA6-HOXA5 locus facilitates colon cancer cell growth. BMC cancer, 19(1), 1-14.

Li, D., Bai, Y., Feng, Z., Li, W., Yang, C., Guo, Y., ... & Li, X. (2019). Study of promoter methylation patterns of HOXA2, HOXA5, and HOXA6 and its clinicopathological characteristics in colorectal cancer. Frontiers in oncology, 9, 394.

Pan, W., Pang, L. J., Cai, H. L., Wu, Y., Zhang, W., & Fang, J. C. (2019). MiR-1294 acts as a tumor suppressor in clear cell renal cell carcinoma through targeting HOXA6. European Review for Medical & Pharmacological Sciences, 23(9).

Wu, F., Wu, S., Tong, H., He, W., & Gou, X. (2019). HOXA6 inhibits cell proliferation and induces apoptosis by suppressing the PI3K/Akt signaling pathway in clear cell renal cell carcinoma. International Journal of Oncology, 54(6), 2095-2105.

Guo, D., Yang, L., Shi, K., & Zhang, S. (2019). Role of aberrant methylation of HOXA6 and HOXA7 genes in tissue and plasma cfDNA in the diagnosis of lung cancer. Genomics and Applied Biology, 38(10), 4732-4737.

Wu, S., Wu, F., & Jiang, Z. (2018). Effect of HOXA6 on the proliferation, apoptosis, migration and invasion of colorectal cancer cells. International Journal of Oncology, 52(6), 2093-2100.

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For research use only. Not intended for any clinical use.

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