Mouse Anti-HOXA6 Recombinant Antibody (CBFYH-1748) (CBMAB-H2755-FY)

Name: Mouse Anti-HOXA6 Recombinant Antibody (CBFYH-1748)
SKU: CBMAB-H2755-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-1748

Application

Immunogen

Synthetic peptide corresponding to the middle region of human HOXA6

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

homeobox A6

Introduction

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.

Entrez Gene ID

3203

UniProt ID

P31267

Alternative Names

Homeobox A6; Homeobox Protein Hox-1B; Homeo Box A6; HOX1B; Homeobox Protein Hox-A6; Homeobox Protein HOXA6; Homeo Box 1B; HOX1.2; HOX1

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Xiulin, J., Wang, C., Guo, J., Wang, C., Pan, C., & Nie, Z. (2022). Next-generation sequencing identifies HOXA6 as a novel oncogenic gene in low grade glioma. Aging (Albany NY), 14(6), 2819.

Lin, J., Zhu, H., Hong, L., Tang, W., Wang, J., Hu, H., ... & Liu, S. (2021). Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer. Aging (Albany NY), 13(5), 6606.

Deng, J., Ding, H. H., Long, J. L., Lin, S. Y., Liu, M., Zhang, X. Q., ... & Ruan, X. (2020). Oxaliplatin‐induced neuropathic pain involves HOXA6 via a TET1‐dependent demethylation of the SOX10 promoter. International Journal of Cancer, 147(9), 2503-2514.

Saijo, S., Kuwano, Y., Tange, S., Rokutan, K., & Nishida, K. (2019). A novel long non-coding RNA from the HOXA6-HOXA5 locus facilitates colon cancer cell growth. BMC cancer, 19(1), 1-14.

Li, D., Bai, Y., Feng, Z., Li, W., Yang, C., Guo, Y., ... & Li, X. (2019). Study of promoter methylation patterns of HOXA2, HOXA5, and HOXA6 and its clinicopathological characteristics in colorectal cancer. Frontiers in oncology, 9, 394.

Pan, W., Pang, L. J., Cai, H. L., Wu, Y., Zhang, W., & Fang, J. C. (2019). MiR-1294 acts as a tumor suppressor in clear cell renal cell carcinoma through targeting HOXA6. European Review for Medical & Pharmacological Sciences, 23(9).

Wu, F., Wu, S., Tong, H., He, W., & Gou, X. (2019). HOXA6 inhibits cell proliferation and induces apoptosis by suppressing the PI3K/Akt signaling pathway in clear cell renal cell carcinoma. International Journal of Oncology, 54(6), 2095-2105.

Guo, D., Yang, L., Shi, K., & Zhang, S. (2019). Role of aberrant methylation of HOXA6 and HOXA7 genes in tissue and plasma cfDNA in the diagnosis of lung cancer. Genomics and Applied Biology, 38(10), 4732-4737.

Wu, S., Wu, F., & Jiang, Z. (2018). Effect of HOXA6 on the proliferation, apoptosis, migration and invasion of colorectal cancer cells. International Journal of Oncology, 52(6), 2093-2100.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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