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Mouse Anti-HOXB4 Recombinant Antibody (CBT4535) (V2LY-0625-LY78)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4535
Antibody Isotype
IgG2a
Application
IHC

Basic Information

Immunogen
Purified recombinant fragment of human HOXB4 (AA: 16-251) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
HOMEOBOX B4
Entrez Gene ID
3214
UniProt ID
P17483
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Bone marrow development Source: Ensembl
Cell population proliferation Source: Ensembl
Definitive hemopoiesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Hematopoietic stem cell differentiation Source: BHF-UCL
Morphogenesis of an epithelial sheet Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of stem cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Somatic stem cell division Source: Ensembl
Spleen development Source: Ensembl
Cellular Location
Nucleus
More Infomation

Wang, L., Jin, H., Zeng, Y., Tan, Y., Wang, J., Fu, W., ... & Zhou, Z. (2022). HOXB4 Mis-regulation induced by microcystin-LR and correlated with immune infiltration is unfavorable to colorectal cancer prognosis. Frontiers in Oncology, 12, 803493.

Liang, J., Cao, Y., He, M., Li, W., Huang, G., Ma, T., ... & Hu, Y. (2021). AKR1C3 and its transcription factor HOXB4 are promising diagnostic biomarkers for acute myocardial infarction. Frontiers in Cardiovascular Medicine, 8, 694238.

Lei, D., Yang, W. T., & Zheng, P. S. (2021). HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway. Cell Death & Disease, 12(1), 105.

Lin, S., Chen, Q., Zhang, L., Ge, S., Luo, Y., He, W., ... & Zeng, M. (2021). Overexpression of HOXB4 promotes protection of bone marrow mesenchymal stem cells against lipopolysaccharide-induced acute lung injury partially through the activation of Wnt/β-catenin signaling. Journal of Inflammation Research, 14, 3637.

Elcheva, I. A., Wood, T., Chiarolanzio, K., Chim, B., Wong, M., Singh, V., ... & Spiegelman, V. S. (2020). RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1. Leukemia, 34(5), 1354-1363.

Li, N., Gou, J. H., Xiong, J., You, J. J., & Li, Z. Y. (2020). HOXB4 promotes the malignant progression of ovarian cancer via DHDDS. BMC cancer, 20, 1-12.

Dumas, P. Y., Mansier, O., Prouzet-Mauleon, V., Koya, J., Villacreces, A., Brunet De La Grange, P., ... & Lippert, E. (2018). MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms. BMC cancer, 18, 1-11.

Li, Y., Sun, J., Gao, S., Hu, H., & Xie, P. (2018). HOXB4 knockdown enhances the cytotoxic effect of paclitaxel and cisplatin by downregulating ABC transporters in ovarian cancer cells. Gene, 663, 9-16.

Teichweyde, N., Kasperidus, L., Carotta, S., Kouskoff, V., Lacaud, G., Horn, P. A., ... & Klump, H. (2018). HOXB4 promotes hemogenic endothelium formation without perturbing endothelial cell development. Stem Cell Reports, 10(3), 875-889.

AlKusayer, G. M., Pon, J. R., Peng, B., Klausen, C., Lisonkova, S., Kinloch, M., ... & Bedaiwy, M. A. (2018). HOXB4 immunoreactivity in endometrial tissues from women with or without endometriosis. Reproductive Sciences, 25(6), 950-957.

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For research use only. Not intended for any clinical use.

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