HOXB4

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
Full Name
HOMEOBOX B4
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Bone marrow development Source: Ensembl
Cell population proliferation Source: Ensembl
Definitive hemopoiesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Hematopoietic stem cell differentiation Source: BHF-UCL
Morphogenesis of an epithelial sheet Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of stem cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Somatic stem cell division Source: Ensembl
Spleen development Source: Ensembl
Cellular Location
Nucleus
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Anti-HOXB4 antibodies

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Mouse Anti-HOXB4 Recombinant Antibody (CBT4535) (V2LY-0625-LY78)

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Target: HOXB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4535
Application*: IH
Datasheet SDS

Mouse Anti-HOXB4 Recombinant Antibody (CBT3540) (V2LY-0625-LY163)

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Target: HOXB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3540
Application*: WB
Datasheet SDS

Mouse Anti-HOXB4 Recombinant Antibody (CBFYH-1765) (CBMAB-H2773-FY)

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Target: HOXB4
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYH-1765
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-HOXB4 (AA 16-251) Recombinant Antibody (3A2F2) (CBMAB-H2771-FY)

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Target: HOXB4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3A2F2
Application*: E, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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