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HOXB4

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Full Name

HOMEOBOX B4

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Bone marrow development Source: Ensembl
Cell population proliferation Source: Ensembl
Definitive hemopoiesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Hematopoietic stem cell differentiation Source: BHF-UCL
Morphogenesis of an epithelial sheet Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of stem cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Somatic stem cell division Source: Ensembl
Spleen development Source: Ensembl

Cellular Location

Nucleus

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Anti-HOXB4 antibodies

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Mouse Anti-HOXB4 Recombinant Antibody (CBT4535) (V2LY-0625-LY78)

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Target: HOXB4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBT4535

Application*: IH

Mouse Anti-HOXB4 Recombinant Antibody (CBT3540) (V2LY-0625-LY163)

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Target: HOXB4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBT3540

Application*: WB

Mouse Anti-HOXB4 Recombinant Antibody (CBFYH-1765) (CBMAB-H2773-FY)

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Target: HOXB4

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBFYH-1765

Application*: WB, IP, IF, E

Mouse Anti-HOXB4 (AA 16-251) Recombinant Antibody (3A2F2) (CBMAB-H2771-FY)

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Target: HOXB4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3A2F2

Application*: E, IH, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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