Sign in or Register   Sign in or Register
  |  

Mouse Anti-HOXC13 Recombinant Antibody (10D4) (CBMAB-A4059-LY)

The product is antibody recognizes HOXC13. The antibody 10D4 immunoassay techniques such as: WB, ELISA.
See all HOXC13 antibodies
Published Data
Fig. 1 Hoxc13 is expressed in all dep follicles (green: Hoxc13).
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
10D4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXC13 (NP_059106, 132 a.a. ~ 231 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homeobox C13
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq]
Entrez Gene ID
3229
UniProt ID
P31276
Alternative Names
HOX3; HOX3G
Function
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity).
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Anterior/posterior pattern specification Source: Ensembl
Hair follicle development Source: Ensembl
Nail development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Tongue morphogenesis Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Ectodermal dysplasia 9, hair/nail type (ECTD9):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD9 is characterized by hypotrichosis and nail dystrophy without non-ectodermal or other ectodermal manifestations. Hypotrichosis usually occurs after birth with varying degrees of severity, ranging from mild hair loss to complete atrichia, including the loss of scalp hair, beard, eyebrows, eyelashes, axillary hair, and pubic hair. Nail dystrophy affects all 20 digits by causing short fragile nails or spoon nails (koilonychia).

Han, Q., Yan, P., Song, R., Liu, F., & Tian, Q. (2023). HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth. Cell Death & Disease, 14(7), 398.

Zhang, L., Piipponen, M., Liu, Z., Li, D., Bian, X., Niu, G., ... & Xu Landén, N. (2023). Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport. Cell Death & Differentiation, 30(5), 1334-1348.

Wang, T., Li, W., Ye, B., Zhang, S., Lei, X., & Zhang, D. (2021). FTO-stabilized lncRNA HOXC13-AS epigenetically upregulated FZD6 and activated Wnt/β-catenin signaling to drive cervical cancer proliferation, invasion, and EMT. J buon, 26(4), 1279-1291.

Li, W., Zhu, Q., Zhang, S., Liu, L., Zhang, H., & Zhu, D. (2020). HOXC13-AS accelerates cell proliferation and migration in oral squamous cell carcinoma via miR-378g/HOXC13 axis. Oral Oncology, 111, 104946.

Li, C., Cui, J., Zou, L., Zhu, L., & Wei, W. (2020). Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer. Oncology letters, 19(1), 899-907.

Li, X., Wang, Q., Rui, Y., Zhang, C., Wang, W., Gu, J., ... & Ding, Y. (2019). HOXC13‐AS promotes breast cancer cell growth through regulating miR‐497‐5p/PTEN axis. Journal of cellular physiology, 234(12), 22343-22351.

Gao, C., Lu, W., Lou, W., Wang, L., & Xu, Q. (2019). Long noncoding RNA HOXC13‐AS positively affects cell proliferation and invasion in nasopharyngeal carcinoma via modulating miR‐383‐3p/HMGA2 axis. Journal of cellular physiology, 234(8), 12809-12820.

Liu, N., Wang, Z., Liu, D., & Xie, P. (2019). HOXC13-AS-miR-122-5p-SATB1-C-Myc feedback loop promotes migration, invasion and EMT process in glioma. OncoTargets and therapy, 12, 7165.

Wu, L., Ye, Z., Pan, Y., Li, X., Fu, X., Zhang, B., ... & Gao, Q. (2018). Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling. Experimental Cell Research, 369(2), 275-283.

Wang, S., Luo, Z., Zhang, Y., Yuan, D., Ge, W., & Wang, X. (2018). The inconsistent regulation of HOXC13 on different keratins and the regulation mechanism on HOXC13 in cashmere goat (Capra hircus). BMC genomics, 19(1), 1-16.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-HOXC13 Recombinant Antibody (10D4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare