Mouse Anti-HOXC13 Recombinant Antibody (CBFYH-1809) (CBMAB-H0718-FY)

Name: Mouse Anti-HOXC13 Recombinant Antibody (CBFYH-1809)
SKU: CBMAB-H0718-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-1809

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

homeobox C13

Introduction

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.

Entrez Gene ID

3229

UniProt ID

P31276

Alternative Names

Homeobox C13; Homeobox Protein Hox-3G; HOX3G; Homeobox Protein Hox-C13; Homeo Box C13; Homeo Box 3G; NUP98/HOXC13; ECTD9; HOX3

Function

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity).

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Anterior/posterior pattern specification Source: Ensembl
Hair follicle development Source: Ensembl
Nail development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Tongue morphogenesis Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

Ectodermal dysplasia 9, hair/nail type (ECTD9):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD9 is characterized by hypotrichosis and nail dystrophy without non-ectodermal or other ectodermal manifestations. Hypotrichosis usually occurs after birth with varying degrees of severity, ranging from mild hair loss to complete atrichia, including the loss of scalp hair, beard, eyebrows, eyelashes, axillary hair, and pubic hair. Nail dystrophy affects all 20 digits by causing short fragile nails or spoon nails (koilonychia).

Han, Q., Yan, P., Song, R., Liu, F., & Tian, Q. (2023). HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth. Cell Death & Disease, 14(7), 398.

Zhang, L., Piipponen, M., Liu, Z., Li, D., Bian, X., Niu, G., ... & Xu Landén, N. (2023). Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport. Cell Death & Differentiation, 30(5), 1334-1348.

Wang, T., Li, W., Ye, B., Zhang, S., Lei, X., & Zhang, D. (2021). FTO-stabilized lncRNA HOXC13-AS epigenetically upregulated FZD6 and activated Wnt/β-catenin signaling to drive cervical cancer proliferation, invasion, and EMT. J buon, 26(4), 1279-1291.

Li, W., Zhu, Q., Zhang, S., Liu, L., Zhang, H., & Zhu, D. (2020). HOXC13-AS accelerates cell proliferation and migration in oral squamous cell carcinoma via miR-378g/HOXC13 axis. Oral Oncology, 111, 104946.

Li, C., Cui, J., Zou, L., Zhu, L., & Wei, W. (2020). Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer. Oncology letters, 19(1), 899-907.

Li, X., Wang, Q., Rui, Y., Zhang, C., Wang, W., Gu, J., ... & Ding, Y. (2019). HOXC13‐AS promotes breast cancer cell growth through regulating miR‐497‐5p/PTEN axis. Journal of cellular physiology, 234(12), 22343-22351.

Gao, C., Lu, W., Lou, W., Wang, L., & Xu, Q. (2019). Long noncoding RNA HOXC13‐AS positively affects cell proliferation and invasion in nasopharyngeal carcinoma via modulating miR‐383‐3p/HMGA2 axis. Journal of cellular physiology, 234(8), 12809-12820.

Liu, N., Wang, Z., Liu, D., & Xie, P. (2019). HOXC13-AS-miR-122-5p-SATB1-C-Myc feedback loop promotes migration, invasion and EMT process in glioma. OncoTargets and therapy, 12, 7165.

Wu, L., Ye, Z., Pan, Y., Li, X., Fu, X., Zhang, B., ... & Gao, Q. (2018). Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling. Experimental Cell Research, 369(2), 275-283.

Wang, S., Luo, Z., Zhang, Y., Yuan, D., Ge, W., & Wang, X. (2018). The inconsistent regulation of HOXC13 on different keratins and the regulation mechanism on HOXC13 in cashmere goat (Capra hircus). BMC genomics, 19(1), 1-16.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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