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Mouse Anti-HOXC6 Recombinant Antibody (2A4) (CBMAB-A4063-LY)

The product is antibody recognizes HOXC6. The antibody 2A4 immunoassay techniques such as: WB, ELISA.
See all HOXC6 antibodies
Published Data
Fig. 1 Immunohistochemical staining of HOXC6 in HNSCC tissue.
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Fig. 2 Western blot was performed for the expression of HOXC6 and Bcl-2 protein levels.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A4
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXC6 (NP_004494.1, 53 a.a. ~ 142 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homeobox C6
Introduction
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq]
Entrez Gene ID
3223
UniProt ID
P09630
Alternative Names
CP25; HHO.C8; HOX3; HOX3C
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system development Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Zhao, J., Lin, H., Huang, K., & Li, S. (2022). Cancer-associated fibroblasts-derived extracellular vesicles carrying lncRNA SNHG3 facilitate colorectal cancer cell proliferation via the miR-34b-5p/HuR/HOXC6 axis. Cell Death Discovery, 8(1), 346.

Li, D., Zhang, J., Liu, Z., Gong, Y., & Zheng, Z. (2021). Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6. Stem Cell Research & Therapy, 12(1), 1-17.

Xu, J., Yang, B., Wang, L., Zhu, Y., Zhu, X., Xia, Z., ... & Xu, L. (2020). LncRNA BBOX1‐AS1 upregulates HOXC6 expression through miR‐361‐3p and HuR to drive cervical cancer progression. Cell proliferation, 53(7), e12823.

Chen, L., Sun, D. Z., Fu, Y. G., Yang, P. Z., Lv, H. Q., Gao, Y., & Zhang, X. Y. (2020). Upregulation of microRNA-141 suppresses epithelial-mesenchymal transition and lymph node metastasis in laryngeal cancer through HOXC6-dependent TGF-β signaling pathway. Cellular signalling, 66, 109444.

You, X., Zhou, Z., Chen, W., Wei, X., Zhou, H., & Luo, W. (2020). MicroRNA-495 confers inhibitory effects on cancer stem cells in oral squamous cell carcinoma through the HOXC6-mediated TGF-β signaling pathway. Stem Cell Research & Therapy, 11(1), 1-14.

Wang, X., Chen, T., Zhang, Y., Zhang, N., Li, C., Li, Y., ... & Yang, Q. (2019). Long noncoding RNA Linc00339 promotes triple‐negative breast cancer progression through miR‐377‐3p/HOXC6 signaling pathway. Journal of Cellular Physiology, 234(8), 13303-13317.

Zhou, J., Yang, X., Song, P., Wang, H., & Wang, X. (2019). HOXC6 in the prognosis of prostate cancer. Artificial Cells, Nanomedicine, and Biotechnology, 47(1), 2715-2720.

Zhang, F., Ren, C. C., Liu, L., Chen, Y. N., Yang, L., & Zhang, X. A. (2018). HOXC6 gene silencing inhibits epithelial-mesenchymal transition and cell viability through the TGF-β/smad signaling pathway in cervical carcinoma cells. Cancer cell international, 18, 1-16.

Li, P. D., Chen, P., Peng, X., Ma, C., Zhang, W. J., & Dai, X. F. (2018). HOXC6 predicts invasion and poor survival in hepatocellular carcinoma by driving epithelial-mesenchymal transition. Aging (Albany NY), 10(1), 115.

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For research use only. Not intended for any clinical use.

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