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Mouse Anti-HOXD11 Recombinant Antibody (5E7) (CBMAB-A4068-LY)

The product is antibody recognizes HOXD11. The antibody 5E7 immunoassay techniques such as: WB, ELISA.
See all HOXD11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5E7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXD11 (NP_067015, 1 a.a. ~ 76 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homeobox D11
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq]
Entrez Gene ID
3237
UniProt ID
P31277
Alternative Names
HOX4; HOX4F
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anatomical structure development Source: GO_Central
Branching involved in ureteric bud morphogenesis Source: UniProtKB
Dorsal/ventral pattern formation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Desai, S. S., Ravindran, F., Panchal, A., Ojha, N., Jadhav, S., & Choudhary, B. (2023). Whole transcriptome sequencing reveals HOXD11-AGAP3, a novel fusion transcript in the Indian acute leukemia cohort. Frontiers in Genetics, 14, 1100587.

Xiong, R., Long, Q., Zhang, X., Xu, J., Liu, Y., Xiong, L., ... & Liu, K. (2023). HOXD11 upregulates JAM-A and exerts oncogenic properties via NF-κB signaling pathway in esophageal squamous cell carcinoma. Human Cell, 36(1), 244-257.

Tan, X., Liu, Z., Wang, Y., Wu, Z., Zou, Y., Luo, S., ... & Yao, K. (2022). miR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma. Cell Death & Disease, 13(9), 816.

Wang, J., Liu, Z., Zhang, C., Wang, H., Li, A., Liu, B., ... & Gao, Y. (2021). Abnormal expression of HOXD11 promotes the malignant behavior of glioma cells and leads to poor prognosis of glioma patients. PeerJ, 9, e10820.

Sweeney, B., Graziano, T. R., Kjosness, K. M., Kistler, S., Schuetz, E., Thompson, R., & Reno, P. (2021). Differential impact of Hoxa11 and Hoxd11 on pisiform ossification and epiphysis formation.

Goldman, S., Bhavsar, A., Kjosness, K., Kistler, S., Schuetz, E., Stephens, N., ... & Reno, P. (2021). Morphological Changes in Calcanei of Mice with Hoxa11 and Hoxd11 loss‐of‐function mutations. The FASEB Journal, 35.

Bhavsar, A., Goldman, S., Kjosness, K., Schuetz, E., Kistler, S., Thompson, R., & Reno, P. (2021). Influence of Hoxa11 and Hoxd11 on Calcaneus Growth and Ossification. The FASEB Journal, 35.

Li, J., Shang, S., Fang, N., Zhu, Y., Zhang, J., Irwin, D. M., ... & Wang, Z. (2020). Accelerated evolution of limb-related gene Hoxd11 in the common ancestor of cetaceans and ruminants (Cetruminantia). G3: Genes, Genomes, Genetics, 10(2), 515-524.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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