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Mouse Anti-HOXD3 (AA 334-431) Recombinant Antibody (CBFYH-1844) (CBMAB-H2852-FY)

This product is mouse antibody that recognizes HOXD3. The antibody CBFYH-1844 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all HOXD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1844
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: FEPHPMASNG GGFASANLQG SPVYVGGNFV ESMAPASGPV FNLGHLSHPS SASVDYSCAA QIPGNHHHGP CDPHPTYTDL SAHHSSQGRL PEAPKLTH
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 334-431

Target

Full Name
homeobox D3
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.
Entrez Gene ID
3232
UniProt ID
P31249
Alternative Names
Homeobox D3; Homeobox Protein Hox-4A; Homeo Box D3; HOX1D; HOX4A; Hox-4.1, Mouse, Homolog Of; Homeobox Protein Hox-D3; Hox-4.1; HOX4
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: UniProtKB
Cartilage development Source: UniProtKB
Cell-matrix adhesion Source: UniProtKB
Embryonic skeletal system morphogenesis Source: UniProtKB
Notch signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Thyroid gland development Source: UniProtKB
Transcription, DNA-templated Source: UniProtKB
Cellular Location
Nucleus

Cui, Y., Chao, L. V., Wen, Y., Zhao, D., Yang, Y., Qiu, H., & Wang, C. (2022). HOXD3 up-regulating KDM5C promotes malignant progression of diffuse large B-cell lymphoma by decreasing p53 expression. Balkan Medical Journal, 39(1), 30.

Wang, L., Gao, Y., Tong, D., Wang, X., Guo, C., Guo, B., ... & Huang, C. (2021). MeCP2 drives hepatocellular carcinoma progression via enforcing HOXD3 promoter methylation and expression through the HB‐EGF/EGFR pathway. Molecular Oncology, 15(11), 3147-3163.

Lin, S., Zhuang, J., Zhu, L., & Jiang, Z. (2020). Matrine inhibits cell growth, migration, invasion and promotes autophagy in hepatocellular carcinoma by regulation of circ_0027345/miR-345-5p/HOXD3 axis. Cancer cell international, 20, 1-12.

Wang, L., Gao, Y., Zhao, X., Guo, C., Wang, X., Yang, Y., ... & Wang, W. (2020). HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway. Cell Proliferation, 53(8), e12835.

Zhu, Y., Liu, Y., Xiao, B., Cai, H., Liu, M., Ma, L., ... & Wang, F. (2019). The circular RNA PVT1/miR-203/HOXD3 pathway promotes the progression of human hepatocellular carcinoma. Biology open, 8(9), bio043687.

Yang, M. H., Zhao, L., Wang, L., Ou-Yang, W., Hu, S. S., Li, W. L., ... & Wang, S. (2019). Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling. Molecular cancer, 18(1), 1-16.

Wang, J., Zhao, H., Dong, H., Zhu, L., Wang, S., Wang, P., ... & Tan, J. (2019). LAT, HOXD3 and NFE2L3 identified as novel DNA methylation-driven genes and prognostic markers in human clear cell renal cell carcinoma by integrative bioinformatics approaches. Journal of Cancer, 10(26), 6726.

Chang, S. E., Gao, Z., Yang, Y., He, K., Wang, X., Wang, L., ... & Huang, C. (2019). miR-99b-3p is induced by vitamin D3 and contributes to its antiproliferative effects in gastric cancer cells by targeting HoxD3. Biological Chemistry, 400(8), 1079-1086.

Wang, L., Tong, D., Guo, Q., Wang, X., Wu, F., Li, Q., ... & Huang, C. (2018). HOXD3 targeted by miR-203a suppresses cell metastasis and angiogenesis through VEGFR in human hepatocellular carcinoma cells. Scientific reports, 8(1), 2431.

Zhang, Y., Zhang, Q., Cao, Z., Huang, Y., Cheng, S., & Pang, D. (2018). HOXD3 plays a critical role in breast cancer stemness and drug resistance. Cellular Physiology and Biochemistry, 46(4), 1737-1747.

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For research use only. Not intended for any clinical use.

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